Skip to main content
Top
Published in: Journal of Cutaneous Medicine and Surgery 5/2005

01-10-2005 | Case Report

Successful Treatment of Refractory Aquagenic Pruritus with Naltrexone

Authors: Sarah Ingber, Paul D. Cohen

Published in: Journal of Cutaneous Medicine and Surgery | Issue 5/2005

Login to get access

Abstract

Background

Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderately successful treatments include capsaicin cream, UVB phototherapy, and sodium bicarbonate bath water.

Objective

In this case report we describe a 55-year-old female with severe itching following showers. Underlying causes were ruled out with a series of blood tests, a chest X-ray, and serum protein electrophoresis. After multiple treatment failures, her itching was relieved with naltrexone.

Conclusion

Endogenous opiates, like naltrexone, can modify pruritus by influencing the peripheral and central sensation of itch. It has been found to be successful in suppressing the perception of pruritus from many diverse origins including aquagenic pruritus.

Antécédents

Aquagenic pruritus est une sensation intense de picotement qui apparaît immédiatement après le contact avec 1’eau, peu importe sa température. Elle est fréquemment associée à la polycythémie vraie. Les traitements courants, mais souvent inefficaces, comprennent les anticholinergiques et les antihistaminiques. D’autres traitements à succès modéré comprennent les crèmes de capsicine, la photothérapie aux rayons UV et les bains au bicarbonate de soude.

Objectifs

Le présent rapport de cas décrit la situation d’une femme âgée de 55 ans qui souffre de démangeaison aiguë après les douches. Une série de prélèvements sanguins, des radiographies pulmonaires et des électrophorèses des protéines sériques ont permis d’éliminer les causes sous-jacentes possibles. Après l’échec de multiples traitements, sa démangeaison a été soignée grâce au naltrexone.

Conclusion

Les agents endogènes opiacés, tels que naltrexone, peuvent modifier le prurit en agissant sur la sensation centrale et périphérique de démangeaison. Ce traitement semble efficace sur toute sorte de prurit, y compris le prurit lié à 1’eau.
Literature
2.
go back to reference Habif TP. Clinical Dermatology, 4th ed., St. Louis: CV Mosby Inc., 2004 Habif TP. Clinical Dermatology, 4th ed., St. Louis: CV Mosby Inc., 2004
3.
go back to reference Archer CB, Camp RDR, Greaves MW. Polycythaemia vera can present with aquagenic pruritus. Lancet 1988; 1:1451PubMedCrossRef Archer CB, Camp RDR, Greaves MW. Polycythaemia vera can present with aquagenic pruritus. Lancet 1988; 1:1451PubMedCrossRef
4.
go back to reference McGrath JA, Greaves MW. Aquagenic pruritus and the myelodysplastic syndrome. Br J Dermatol 1990; 123:414–415PubMedCrossRef McGrath JA, Greaves MW. Aquagenic pruritus and the myelodysplastic syndrome. Br J Dermatol 1990; 123:414–415PubMedCrossRef
5.
go back to reference Newton JA, Singh AS, Greaves MW, et al. Aquagenic pruritus associated with the idiopathic hypereosinophilic syndrome. Br J Dermatol 1990; 122:103–106PubMedCrossRef Newton JA, Singh AS, Greaves MW, et al. Aquagenic pruritus associated with the idiopathic hypereosinophilic syndrome. Br J Dermatol 1990; 122:103–106PubMedCrossRef
6.
go back to reference Ferguson JE, August PJ, Guy AJ. Aquagenic pruritus associated with metastatic squamous cell carcinoma of the cervix. Clin Exp Dermatol 1994; 19:257–258PubMedCrossRef Ferguson JE, August PJ, Guy AJ. Aquagenic pruritus associated with metastatic squamous cell carcinoma of the cervix. Clin Exp Dermatol 1994; 19:257–258PubMedCrossRef
8.
go back to reference Summerfield JA. Naloxone modulates the perception of itch in man. Br J Clin Pharmacol 1980; 10:180–183PubMed Summerfield JA. Naloxone modulates the perception of itch in man. Br J Clin Pharmacol 1980; 10:180–183PubMed
9.
go back to reference Ko MC, Song MS, Edwards T, et al. The role of central μ receptors in opioid induced itch in primates. J Pharamcol Exp Ther 2004 Jul; 310(1):169–176CrossRef Ko MC, Song MS, Edwards T, et al. The role of central μ receptors in opioid induced itch in primates. J Pharamcol Exp Ther 2004 Jul; 310(1):169–176CrossRef
10.
go back to reference Metze D, Reimann S, Beissert S, et al. Efficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases. J Am Acad Dermatol 1999 Oct; 41(4):533–539 Metze D, Reimann S, Beissert S, et al. Efficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases. J Am Acad Dermatol 1999 Oct; 41(4):533–539
11.
go back to reference Shelley, Walter B. Classics in Clinical Dermatology. New York: Parthenon Publishing Group, 2003, pp 916–918 Shelley, Walter B. Classics in Clinical Dermatology. New York: Parthenon Publishing Group, 2003, pp 916–918
Metadata
Title
Successful Treatment of Refractory Aquagenic Pruritus with Naltrexone
Authors
Sarah Ingber
Paul D. Cohen
Publication date
01-10-2005
Publisher
Springer-Verlag
Published in
Journal of Cutaneous Medicine and Surgery / Issue 5/2005
Print ISSN: 1203-4754
Electronic ISSN: 1615-7109
DOI
https://doi.org/10.1007/s10227-005-0144-x

Other articles of this Issue 5/2005

Journal of Cutaneous Medicine and Surgery 5/2005 Go to the issue

OriginalPaper

8. Pathology

OriginalPaper

12. Cancer