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European Journal of Applied Physiology

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Open Access 01-09-2019 | Original Article

Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia

Authors: Alex Griffiths, Kevin Deighton, Oliver M. Shannon, Jamie Matu, Roderick King, John P. O’Hara

Published in: European Journal of Applied Physiology | Issue 9/2019

Abstract

Purpose

Previous research has reported inconsistent effects of hypoxia on substrate oxidation, which may be due to differences in methodological design, such as pre-exercise nutritional status and exercise intensity. This study investigated the effect of breakfast consumption on substrate oxidation at varying exercise intensities in normobaric hypoxia compared with normoxia.

Methods

Twelve participants rested and exercised once after breakfast consumption and once after omission in normobaric hypoxia (4300 m: F_iO₂ ~ 11.7%) and normoxia. Exercise consisted of walking for 20 min at 40%, 50% and 60% of altitude-specific \(\dot{\text{V}}\)O_2max at 10–15% gradient with a 10 kg backpack. Indirect calorimetry was used to calculate carbohydrate and fat oxidation.

Results

The relative contribution of carbohydrate oxidation to energy expenditure was significantly reduced in hypoxia compared with normoxia during exercise after breakfast omission at 40% (22.4 ± 17.5% vs. 38.5 ± 15.5%, p = 0.03) and 60% \(\dot{\text{V}}\)O_2max (35.4 ± 12.4 vs. 50.1 ± 17.6%, p = 0.03), with a trend observed at 50% \(\dot{\text{V}}\)O_2max (23.6 ± 17.9% vs. 38.1 ± 17.0%, p = 0.07). The relative contribution of carbohydrate oxidation to energy expenditure was not significantly different in hypoxia compared with normoxia during exercise after breakfast consumption at 40% (42.4 ± 15.7% vs. 48.5 ± 13.3%, p = 0.99), 50% (43.1 ± 11.7% vs. 47.1 ± 14.0%, p = 0.99) and 60% \(\dot{\text{V}}\)O_2max (54.6 ± 17.8% vs. 55.1 ± 15.0%, p = 0.99).

Conclusions

Relative carbohydrate oxidation was significantly reduced in hypoxia compared with normoxia during exercise after breakfast omission but not during exercise after breakfast consumption. This response remained consistent with increasing exercise intensities. These findings may explain some of the disparity in the literature.

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Title: Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia
Authors: Alex Griffiths
Kevin Deighton
Oliver M. Shannon
Jamie Matu
Roderick King
John P. O’Hara
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 9/2019
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04179-6

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Substrate oxidation and the influence of breakfast in normobaric hypoxia and normoxia

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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