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01-02-2010 | Original Article

Subclinical atherosclerosis and related risk factors in renal transplant recipients

Authors: Mitra Basiratnia, Mojtaba Fazel, Mehrzad Lotfi, Ghamar Hosseini Al-Hashemi, Mohammad Hossein Fallahzadeh, Ali Derakhshan, Mahdi Salehipour

Published in: Pediatric Nephrology | Issue 2/2010

Abstract

Long-term survival after successful renal transplantation is shortened by cardiovascular disease. Cardiovascular disease is a main cause of morbidity and death among children and young adults after renal transplantation. The aim of our study was to measure the carotid intima media thickness (cIMT) and determine its relationship to the risk factors for early arteriopathy in renal transplant recipients. Sixty-six stable renal transplant patients (36 female and 30 male), 7–25 years of age (mean 18.3 ± 4.5 years) were enrolled in this study. The cIMT was measured by high-resolution B mode ultrasonography in multiple projections. The results were correlated with clinical and paraclinical parameters, including age, gender, body mass index (BMI), blood pressure, glomerular filtration rate (GFR), duration of dialysis, duration of chronic kidney disease (CKD), post-transplantation interval, calcium–phosphate (Ca×P) product, cumulative dose of Ca-based P binder and calcitriol, lipid profile, uric acid, and cyclosporine level. The mean post-transplantation follow-up period was 64 ± 40 months. The mean cIMT standard deviation score (SDS) of the patients and the control group was 0.60 ± 0.81 mm (range −1.10 mm to 2.75 mm) and −1.25 ± 0.95 mm (range −3.23 mm to 0.26 mm), respectively. Renal transplant recipients had a significantly greater cIMT than that of the controls (P < 0.001). Among several risk factors, there were positive correlations between cIMT SDS and gender, and cumulative dose of calcitriol (P = 0.02 and P = 0.02, respectively). In conclusion, subclinical atherosclerosis is present in young transplant recipients. Non-invasive monitoring of cIMT in renal transplant patients for the detection of early vascular lesions might be of value in preventing cardiovascular disease. Further studies are needed to see if proper monitoring of vitamin D therapy before and after transplantation could be helpful in the prevention of arteriopathy in renal transplant recipients.

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Title: Subclinical atherosclerosis and related risk factors in renal transplant recipients
Authors: Mitra Basiratnia
Mojtaba Fazel
Mehrzad Lotfi
Ghamar Hosseini Al-Hashemi
Mohammad Hossein Fallahzadeh
Ali Derakhshan
Mahdi Salehipour
Publication date: 01-02-2010
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 2/2010
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1345-0

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Subclinical atherosclerosis and related risk factors in renal transplant recipients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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