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01-03-2009

Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage

Authors: Janet Mans, Li Zhi, Maria Jamela R. Revilleza, Lee Smith, Alec Redwood, Kannan Natarajan, David H. Margulies

Published in: Immunologic Research | Issue 1-3/2009

Abstract

The mouse cytomegalovirus (CMV), a β-herpesvirus, exploits its large (~230 kb) double-stranded DNA genome for both essential and non-essential functions. Among the non-essential functions are those that offer the virus a selective advantage in eluding both the innate and adaptive immune responses of the host. Several non-essential genes of MCMV are thought to encode MHC-I-like genes and to function as immunoevasins. To understand further the evolution and function of these viral MHC-I (MHC-Iv) molecules, X-ray structures of several of them have been determined, not only confirming the overall MHC-I-like structure, but also elucidating features unique to this family. Future efforts promise to clarify the nature of the molecular ligands of these molecules, their evolution in the context of the adapting immune response of the murine host, and by analogy the evolution of the host response to human CMV as well.

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Title: Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage
Authors: Janet Mans
Li Zhi
Maria Jamela R. Revilleza
Lee Smith
Alec Redwood
Kannan Natarajan
David H. Margulies
Publication date: 01-03-2009
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2009
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-008-8081-6

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Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage

Abstract

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Abstract

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