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Trials
Published in: Trials 1/2022

Open Access 01-12-2022 | Stroke | Study protocol

Intensity matters: protocol for a randomized controlled trial exercise intervention for individuals with chronic stroke

Authors: Lynden Rodrigues, Kevin Moncion, Janice J. Eng, Kenneth S. Noguchi, Elise Wiley, Bernat de Las Heras, Shane N. Sweet, Joyce Fung, Marilyn MacKay-Lyons, Aimee J. Nelson, Diogo Medeiros, Jennifer Crozier, Alexander Thiel, Ada Tang, Marc Roig

Published in: Trials | Issue 1/2022

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Abstract

Rationale

Cardiovascular exercise is an effective method to improve cardiovascular health outcomes, but also promote neuroplasticity during stroke recovery. Moderate-intensity continuous cardiovascular training (MICT) is an integral part of stroke rehabilitation, yet it may remain a challenge to exercise at sufficiently high intensities to produce beneficial adaptations to neuroplasticity. High-intensity interval training (HIIT) could provide a viable alternative to achieve higher intensities of exercise by using shorter bouts of intense exercise interspersed with periods of recovery.

Methods and design

This is a two-arm, parallel-group multi-site RCT conducted at the Jewish Rehabilitation Hospital (Laval, Québec, Canada) and McMaster University (Hamilton, Ontario, Canada). Eighty participants with chronic stroke will be recruited at both sites and will be randomly allocated into a HIIT or MICT individualized exercise program on a recumbent stepper, 3 days per week for 12 weeks. Outcomes will be assessed at baseline, at 12 weeks post-intervention, and at an 8-week follow-up.

Outcomes

The primary outcome is corticospinal excitability, a neuroplasticity marker in brain motor networks, assessed with transcranial magnetic stimulation (TMS). We will also examine additional markers of neuroplasticity, measures of cardiovascular health, motor function, and psychosocial responses to training.

Discussion

This trial will contribute novel insights into the effectiveness of HIIT to promote neuroplasticity in individuals with chronic stroke.

Trial registration

ClinicalTrials.​govNCT03614585. Registered on 3 August 2018
Appendix
Available only for authorised users
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Metadata
Title
Intensity matters: protocol for a randomized controlled trial exercise intervention for individuals with chronic stroke
Authors
Lynden Rodrigues
Kevin Moncion
Janice J. Eng
Kenneth S. Noguchi
Elise Wiley
Bernat de Las Heras
Shane N. Sweet
Joyce Fung
Marilyn MacKay-Lyons
Aimee J. Nelson
Diogo Medeiros
Jennifer Crozier
Alexander Thiel
Ada Tang
Marc Roig
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-022-06359-w

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