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13-07-2022 | Stroke | Original Article

High serum total cholesterol associated with good outcome in endovascular thrombectomy for acute large artery occlusion

Authors: Sang Hee Ha, Jae-Chan Ryu, Jae-Han Bae, Sujin Koo, Boseong Kwon, Yunsun Song, Deok Hee Lee, Jun Young Chang, Dong-Wha Kang, Sun U. Kwon, Jong S. Kim, Bum Joon Kim

Published in: Neurological Sciences | Issue 10/2022

Abstract

Background

The effect of cholesterol on the functional outcome after endovascular thrombectomy (EVT) is still controversial. This study aimed to investigate whether the lipid profile is associated with the EVT prognosis.

Methods

We retrospectively analyzed patients with emergent large vessel occlusion who underwent EVT. The blood lipid levels were measured in the fasting state, 1 day after admission. We divided patients into terciles of serum total cholesterol (TC) levels and compared the clinical characteristics among the groups. The factors associated with a good outcome at 3 months (modified Rankin scale 0–2) were investigated, considering the stroke mechanism and recanalization status.

Results

Among 274 patients, good outcomes were observed in 108 (39.4%) patients. Low initial severity (odds ratio (OR), 0.91, 95% confidence interval (CI), 0.858–0.954; p < 0.001) and high TC level (1.35, 1.034–1.758; p = 0.041) were associated with good outcomes. In patients with cardioembolism, young age (0.95, 0.915–0.991; p = 0.021), low initial severity (0.92, 0.857–0.988; p = 0.024), and high TC level (1.60, 1.019–2.499; p = 0.036) were associated with good outcomes. The lipid profile was not associated with a functional outcome in those with large artery atherosclerosis. In patients with complete recanalization, young age (0.97, 0.941–0.994; p = 0.016), low initial severity (0.91, 0.864–0.961; p = 0.001), absence of diabetes (0.45, 0.218–0.947; p = 0.035) or any hemorrhage (0.33, 0.142–0.760; p = 0.009), and high TC level (1.40, 1.031–1.879; p = 0.031) were associated with good outcomes.

Conclusions

A high TC level was associated with favorable outcomes after EVT, especially in patients with cardioembolism and complete recanalization.

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Title: High serum total cholesterol associated with good outcome in endovascular thrombectomy for acute large artery occlusion
Authors: Sang Hee Ha
Jae-Chan Ryu
Jae-Han Bae
Sujin Koo
Boseong Kwon
Yunsun Song
Deok Hee Lee
Jun Young Chang
Dong-Wha Kang
Sun U. Kwon
Jong S. Kim
Bum Joon Kim
Publication date: 13-07-2022
Publisher: Springer International Publishing
Keywords: Stroke
Thrombectomy
Published in: Neurological Sciences / Issue 10/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06269-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High serum total cholesterol associated with good outcome in endovascular thrombectomy for acute large artery occlusion

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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