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Neuroradiology

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01-10-2019 | Stroke | Diagnostic Neuroradiology

Predictive value of the combination of lesion location and volume of ischemic infarction with rehabilitation outcomes

Authors: Chen Lin, Neil Chatterjee, Jungwha Lee, Richard Harvey, Shyam Prabhakaran

Published in: Neuroradiology | Issue 10/2019

Abstract

Purpose

In acute ischemic stroke, infarct location and volume have, separately, been used to determine long-term outcomes after stroke. Little information exists on the combination of these imaging characteristics on rehabilitation outcomes. We evaluated the association between infarct lesion location volume with the Functional Independence Measure (FIM) measure during inpatient rehabilitation facility (IRF) in ischemic stroke patients.

Methods

Between 2012 and 2014, we prospectively enrolled consecutive acute ischemic stroke patients admitted from a Comprehensive Stroke Center and followed to an IRF in Chicago, Illinois. We adjudicated infarct volumes in specific lesion locations using a validated brain atlas. Volumes were calculated using an automated pipeline. FIM measure was extracted from IRF charts. We analyzed the association between acute infarct characteristics and functional measures using adjusted Spearman’s correlation.

Results

Among 162 stroke patients (mean age 67.6 years, 48.1% male, 58.6% Caucasian), the median FIM at IRF was 52 (IQR 36–62). In an adjusted analysis, infarct volumes in the left basal ganglia (r_s = − 0.45, p = 0.02) and left frontal lobe (r_s = − 0.38, p = 0.04) were negatively correlated with FIM scores.

Conclusions

There is an association between specific infarct lesion location volume and subsequent FIM scores assessed at IRF. Our findings suggest that imaging during index stroke hospitalization could be used to predict outcomes assessed during IRF.

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Title: Predictive value of the combination of lesion location and volume of ischemic infarction with rehabilitation outcomes
Authors: Chen Lin
Neil Chatterjee
Jungwha Lee
Richard Harvey
Shyam Prabhakaran
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keyword: Stroke
Published in: Neuroradiology / Issue 10/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-019-02234-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive value of the combination of lesion location and volume of ischemic infarction with rehabilitation outcomes

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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