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BMC Neurology

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01-12-2020 | Stroke | Research article

Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke

Authors: Sang Hee Ha, Yeon-Jung Kim, Sung Hyuk Heo, Dae-il Chang, Bum Joon Kim

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke.

Methods

Acute ischemic stroke patients received lower extremity ultrasonography (LEUS) to diagnose the presence of DVT. Clinical characteristics and laboratory results, including D-dimer level, were compared between patients with and without DVT. Independent risk factors for DVT were investigated using multivariable analysis. Similar analysis was performed to identify factors associated with elevated D-dimer level (> 0.5 mg/dl) in acute ischemic stroke patients.

Results

During the study period, 289 patients were enrolled, and 38 (13.1%) showed DVT. Female sex (OR = 2.579, 95% CI = 1.224–5.432; p = 0.013) and a high National Institutes of Health Stroke Scale (NIHSS) score (OR = 1.191 95% CI = 1.095–1.294; p = 0.005) were independently associated with the presence of DVT, although D-dimer level was not. Stroke mechanism, especially cardioembolic stroke (OR = 3.777, 95% CI = 1.532–9.313; p = 0.004; reference: large artery atherosclerosis), NIHSS score (OR = 1.087, 95% CI = 1.002–1.179; p = 0.001) and thrombolysis (OR = 12.360, 95% CI 2.456–62.213; p = 0.002) were independently associated with elevated abnormal D-dimer levels.

Conclusion

The severity of ischemic stroke, but not the D-dimer level, was associated with the presence of DVT in Asian ischemic stroke patients. D-dimer level was influenced by the stroke mechanism. LEUS in patients with severe neurological deficit, rather than screening with D-dimer, may be more beneficial for diagnosing DVT in Asian patients with acute ischemic stroke.

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Title: Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke
Authors: Sang Hee Ha
Yeon-Jung Kim
Sung Hyuk Heo
Dae-il Chang
Bum Joon Kim
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Stroke
Phlebothrombosis
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01842-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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