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Acta Neurologica Belgica

Published in:

11-11-2023 | Stroke | Original article

Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis

Authors: Zhuo-Rao Wu, Tian-Qi Zhou, Shuang-Chun Ai

Published in: Acta Neurologica Belgica | Issue 2/2024

Abstract

Background and objective

A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.

Methods

The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.

Results

The researchers included 752 patients in 7 studies (4 case–control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38), P < 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53), P = 0.003].

Conclusion

The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022356619.

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Title: Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis
Authors: Zhuo-Rao Wu
Tian-Qi Zhou
Shuang-Chun Ai
Publication date: 11-11-2023
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Acta Neurologica Belgica / Issue 2/2024
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-023-02409-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis

Abstract

Background and objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and objective

Methods

Results

Conclusion

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