Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Clinical Neuroradiology
Published in: Clinical Neuroradiology 4/2021

01-12-2021 | Stroke | Correspondence

Molecular MR-Imaging in Thromboembolic Stroke Using a Fibrin-Specific Contrast Agent in Patients at 3 Tesla

Authors: Elmar Spuentrup, Rene Botnar, Andreas Binder, Marcus Katoh, Carolin Spüntrup

Published in: Clinical Neuroradiology | Issue 4/2021

Login to get access

Excerpt

Thromboembolic stroke may be caused by carotid artery plaque rupture, symptomatic aortic plaque burden or thrombi in the heart chambers (e.g. left ventricle or left atrial appendage). For diagnostic work-up different imaging modalities including computed tomography (CT), magnetic resonance (MR) imaging, duplex ultrasound and echocardiography can all be performed. MR imaging enables dedicated structural imaging of the brain, imaging of the vessel lumen (MR-angiography) and imaging of the heart chambers. While these imaging techniques have been substantially improved over the last decades, the original and underlying cause of the embolism remains unclear in a significant number of patients. …
Literature
1.
Kopczak A, Schindler A, Bayer-Karpinska A, Koch ML, Sepp D, Zeller J, Strecker C, Hempel JM, Yuan C, Malik R, Wollenweber FA, Boeckh-Behrens T, Cyran CC, Helck A, Harloff A, Ziemann U, Poli S, Poppert H, Dichgans M, Saam T. Complicated Carotid Artery Plaques as a Cause of Cryptogenic Stroke. J Am Coll Cardiol. 2020;76:2212–22.CrossRef
2.
Saba L, Saam T, Jäger HR, Yuan C, Hatsukami TS, Saloner D, Wasserman BA, Bonati LH, Wintermark M. Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol. 2019;18:559–72.CrossRef
3.
Hajhosseiny R, Bahaei TS, Prieto C, Botnar RM. Molecular and nonmolecular magnetic resonance coronary and carotid imaging. Arterioscler Thromb Vasc Biol. 2019;39:569–82.CrossRef
4.
Phinikaridou A, Andia ME, Lacerda S, Lorrio S, Makowski MR, Botnar RM. Molecular MRI of atherosclerosis. Molecules. 2013;18:14042–69.CrossRef
5.
Spuentrup E, Botnar RM. Coronary magnetic resonance imaging: visualization of the vessel lumen and the vessel wall and molecular imaging of arteriothrombosis. Eur Radiol. 2006;16:1–14.CrossRef
6.
Spuentrup E, Fausten B, Kinzel S, Wiethoff AJ, Botnar RM, Graham PB, Haller S, Katoh M, Parsons EC Jr, Manning WJ, Busch T, Günther RW, Buecker A. Molecular magnetic resonance imaging of atrial clots in a swine model. Circulation. 2005;112:396–9.CrossRef
7.
Spuentrup E, Buecker A, Katoh M, Wiethoff AJ, Parsons EC Jr, Botnar RM, Weisskoff RM, Graham PB, Manning WJ, Günther RW. Molecular magnetic resonance imaging of coronary thrombosis and pulmonary emboli with a novel fibrin-targeted contrast agent. Circulation. 2005;111:1377–82.CrossRef
8.
Botnar RM, Buecker A, Wiethoff AJ, Parsons EC Jr, Katoh M, Katsimaglis G, Weisskoff RM, Lauffer RB, Graham PB, Gunther RW, Manning WJ, Spuentrup E. In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent. Circulation. 2004;110:1463–6.CrossRef
9.
Spuentrup E, Katoh M, Wiethoff AJ, Parsons EC Jr, Botnar RM, Mahnken AH, Günther RW, Buecker A. Molecular magnetic resonance imaging of pulmonary emboli with a fibrin-specific contrast agent. Am J Respir Crit Care Med. 2005;172:494–500.CrossRef
10.
Stracke CP, Katoh M, Wiethoff AJ, Parsons EC, Spangenberg P, Spüntrup E. Molecular MRI of cerebral venous sinus thrombosis using a new fibrin-specific MR contrast agent. Stroke. 2007;38:1476–81.CrossRef
11.
Spuentrup E, Botnar RM, Wiethoff AJ, Ibrahim T, Kelle S, Katoh M, Ozgun M, Nagel E, Vymazal J, Graham PB, Günther RW, Maintz D. MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients. Eur Radiol. 2008;18:1995–2005.CrossRef
12.
Vymazal J, Spuentrup E, Cardenas-Molina G, Wiethoff AJ, Hartmann MG, Caravan P, Parsons EC Jr. Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility. Invest Radiol. 2009;44:697–704.CrossRef
13.
14.
Schindler A, Schinner R, Altaf N, Hosseini AA, Simpson RJ, Esposito-Bauer L, Singh N, Kwee RM, Kurosaki Y, Yamagata S, Yoshida K, Miyamoto S, Maggisano R, Moody AR, Poppert H, Kooi ME, Auer DP, Bonati LH, Saam T. Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. JACC Cardiovasc Imaging. 2020;13:395–406.CrossRef
15.
Shuvaev S, Akam E, Caravan P. Molecular MR contrast agents. Invest Radiol. 2021;56:20–34.CrossRef
16.
Katoh M, Haage P, Wiethoff AJ, Günther RW, Bücker A, Tacke J, Spuentrup E. Molecular magnetic resonance imaging of deep vein thrombosis using a fibrin-targeted contrast agent: a feasibility study. Invest Radiol. 2009;44:146–50.CrossRef
17.
Uppal R, Ay I, Dai G, Kim YR, Sorensen AG, Caravan P. Molecular MRI of intracranial thrombus in a rat ischemic stroke model. Stroke. 2010;41:1271–7.CrossRef
Metadata
Title
Molecular MR-Imaging in Thromboembolic Stroke Using a Fibrin-Specific Contrast Agent in Patients at 3 Tesla
Authors
Elmar Spuentrup
Rene Botnar
Andreas Binder
Marcus Katoh
Carolin Spüntrup
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Keyword
Stroke
Published in
Clinical Neuroradiology / Issue 4/2021
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-021-01052-y

Other articles of this Issue 4/2021

Clinical Neuroradiology 4/2021 Go to the issue

Letter to the Editor

In Reply: Practicability and Diagnostic Yield of One-Stop Stroke CT with Delayed-Phase Cardiac CT in Detecting Major Cardioembolic Sources of Acute Ischemic Stroke

Original Article

DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study

Original Article

Quantitative Assessment of Hyperdense Sign Measured by Hounsfield Units is Associated with Unsuccessful Mechanical Thrombectomy

Correspondence

Partial Neuritis of a Bifid Median Nerve

Original Article

Diagnostic Accuracy of Quantitative Imaging Biomarkers in the Differentiation of Benign and Malignant Vertebral Lesions

Original Article

Dual Testing to Achieve Low On-treatment Platelet Reactivity for Aneurysm Embolization