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Neurological Sciences

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01-03-2021 | Stroke | Original Article

High plasma levels of trimethylamine N-oxide are associated with poor outcome in intracerebral hemorrhage patients

Authors: Qijin Zhai, Taipeng Sun, Chuanfu Sun, Luxia Yan, Xiang Wang, Yuqian Wang, Junshan Sun, Ying Zhao

Published in: Neurological Sciences | Issue 3/2021

Abstract

Background and aims

As a gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO) has been implicated in cardiovascular diseases. We aimed to investigate the relationship between the clinical outcomes and plasma TMAO concentrations in patients with acute intracerebral hemorrhage.

Methods

From January 2019 to October 2019, we prospectively enrolled intracerebral hemorrhage patients diagnosed within 6 h of symptoms onset. Plasma TMAO levels was measured for all patients within 24 h after admission. The primary outcome was functional outcome at 3 months. Patients were dichotomized as good (modified Rankin scale 0–3) and poor (modified Rankin scale 4–6). Secondary outcome included early neurological deterioration (END) and hematoma enlargement (HE).

Results

There were 307 patients (57.7% male) with a mean age of 66.8 years included in the study. The median TMAO levels was 3.2 μmol/L. END, HE, and 3-month poor outcome were detected in 59 (19.2%), 54 (17.6%), and 139 (45.3%) patients, respectively. After adjusting for potential confounders, the odds ratio for the highest quartile of TMAO compared with the lowest quartile was 3.65 (95% confidence interval, 1.43–9.30) for 3-month poor outcome. Furthermore, multiple-adjusted spline regression model showed a linear association between TMAO levels and poor outcome at 3 months (P = 0.013 for linearity). Similar significant findings were observed when functional outcome was analyzed by continuous mRS score. No association was found between TMAO levels and END and HE.

Conclusions

The present study demonstrated that increased TMAO levels were independently correlated with 3-month function outcome after intracerebral hemorrhage.

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Title: High plasma levels of trimethylamine N-oxide are associated with poor outcome in intracerebral hemorrhage patients
Authors: Qijin Zhai
Taipeng Sun
Chuanfu Sun
Luxia Yan
Xiang Wang
Yuqian Wang
Junshan Sun
Ying Zhao
Publication date: 01-03-2021
Publisher: Springer International Publishing
Keywords: Stroke
Hematoma
Respiratory Microbiota
Published in: Neurological Sciences / Issue 3/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04618-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High plasma levels of trimethylamine N-oxide are associated with poor outcome in intracerebral hemorrhage patients

Abstract

Background and aims

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and aims

Methods

Results

Conclusions

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