Skip to main content
Top
Published in: The Journal of Headache and Pain 1/2022

Open Access 01-12-2022 | Stroke | Research

De novo headache in ischemic stroke patients treated with thrombectomy: a prospective study

Authors: Daniel Gallo, Leire Manrique, Marcos Polanco, Andrés González-Mandly, Eduardo Torres, Enrique Palacio, José Luis Vázquez, Sara Pérez-Pereda, Vicente González-Quintanilla, Jorge Madera, Julio Pascual

Published in: The Journal of Headache and Pain | Issue 1/2022

Login to get access

Abstract

Background and aim

Headache attributed to intracranial endovascular procedures is described in the ICHD-3. Our aim was to study the frequency and characteristics of headache specifically related to thrombectomy in patients with ischemic stroke.

Methods

Prospective evaluation of clinical features of headache after thrombectomy using an ad hoc questionnaire.

Results

One hundred seventeen patients were included (52.1% females). Most had an anterior circulation artery occlusion (91.5%). 93 (79.5%) received general anaesthesia. 111 (94.9%) required stent retriever, 21 (24.4%) angioplasty and 19 (16.2%) aspiration thrombectomy. 31 (26.5%; 95% CI 18.8–35.5%) had headache related to thrombectomy, and it was associated with a history of primary headache (p = 0.004). No differences about sex, initial NIHSS score, or the type or complexity of the procedure were observed. Headache was usually moderate and oppressive, ipsilateral to the artery occlusion and usually lasted less than 48 hours.

Conclusions

Almost one-third of patients with ischemic stroke who undergo endovascular thrombectomy experience headache in the first 24 hours, occurring more frequently in patients who had a previous history of headaches regardless of the procedure complexity.
Appendix
Available only for authorised users
Literature
10.
go back to reference Lambrinos A, Schaink AK, Dhalla I, Krings I, Casaubon LK, Sikich N, Lum C, Bharatha A, Mendes Pereira V, Stotts G, Saposnik G, Kelloway L, Xie X, Hill MD (2016) Mechanical thrombectomy in acute ischemic stroke: a systematic review. J Neurol Sci 43(4):455–460. https://doi.org/10.1017/cjn.2016.30CrossRef Lambrinos A, Schaink AK, Dhalla I, Krings I, Casaubon LK, Sikich N, Lum C, Bharatha A, Mendes Pereira V, Stotts G, Saposnik G, Kelloway L, Xie X, Hill MD (2016) Mechanical thrombectomy in acute ischemic stroke: a systematic review. J Neurol Sci 43(4):455–460. https://​doi.​org/​10.​1017/​cjn.​2016.​30CrossRef
11.
go back to reference Berkhemer O, Fransen P, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schoneville WJ, Vos JA, Nederkoorn PJ, Wermer MJH, van Walderveen MAA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama a Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dik LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PLM, van WJJ R, van den Berg JSP, van Hasselt BAAM, Aerden LAM, Dallinga RJ, Visser MC, JCJ B, Vroomen PC, Eshghi O, Schreuder THCML, Jeijboer RJJ, Keizer K, Teilbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers MES, Jenniskens SFM, Beenen LFM, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YBEM, van der Lugt A, Oostenbrugge PJ, Majoie CBLMM, Dippel DWJ, MR CLEAN Investigators (2015) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372(1):11–20. https://doi.org/10.1056/NEJMoa1411587CrossRefPubMed Berkhemer O, Fransen P, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schoneville WJ, Vos JA, Nederkoorn PJ, Wermer MJH, van Walderveen MAA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama a Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dik LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PLM, van WJJ R, van den Berg JSP, van Hasselt BAAM, Aerden LAM, Dallinga RJ, Visser MC, JCJ B, Vroomen PC, Eshghi O, Schreuder THCML, Jeijboer RJJ, Keizer K, Teilbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers MES, Jenniskens SFM, Beenen LFM, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YBEM, van der Lugt A, Oostenbrugge PJ, Majoie CBLMM, Dippel DWJ, MR CLEAN Investigators (2015) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372(1):11–20. https://​doi.​org/​10.​1056/​NEJMoa1411587CrossRefPubMed
12.
go back to reference Goyal M, Demchuk A, Menon B, Eesa M, Rempel JL, Thronton J, Roy D, Jovin TG, Willinsky RA, Spkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Young Bang O, Baxter BW, Burns PA, Choe Hm Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn S, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD, Tial Investigators ESCAPE (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372(11):1019–1030. https://doi.org/10.1056/NEJMoa1414905CrossRefPubMed Goyal M, Demchuk A, Menon B, Eesa M, Rempel JL, Thronton J, Roy D, Jovin TG, Willinsky RA, Spkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Young Bang O, Baxter BW, Burns PA, Choe Hm Heo JH, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn S, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill MD, Tial Investigators ESCAPE (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372(11):1019–1030. https://​doi.​org/​10.​1056/​NEJMoa1414905CrossRefPubMed
13.
go back to reference Saver J, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahn R, SWIFT PRIME Investigators (2015) Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 372(24):2285–2295. https://doi.org/10.1056/NEJMoa1415061CrossRefPubMed Saver J, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahn R, SWIFT PRIME Investigators (2015) Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 372(24):2285–2295. https://​doi.​org/​10.​1056/​NEJMoa1415061CrossRefPubMed
Metadata
Title
De novo headache in ischemic stroke patients treated with thrombectomy: a prospective study
Authors
Daniel Gallo
Leire Manrique
Marcos Polanco
Andrés González-Mandly
Eduardo Torres
Enrique Palacio
José Luis Vázquez
Sara Pérez-Pereda
Vicente González-Quintanilla
Jorge Madera
Julio Pascual
Publication date
01-12-2022
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2022
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-022-01455-3

Other articles of this Issue 1/2022

The Journal of Headache and Pain 1/2022 Go to the issue