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Trials
Published in: Trials 1/2022

Open Access 01-12-2022 | Stroke | Study protocol

Effects of robotic priming of bilateral arm training, mirror therapy, and impairment-oriented training on sensorimotor and daily functions in patients with chronic stroke: study protocol of a single-blind, randomized controlled trial

Authors: Yi-chen Lee, Yi-chun Li, Keh-chung Lin, Grace Yao, Ya-ju Chang, Ya-yun Lee, Chien-ting Liu, Wan-ling Hsu, Yi-hsuan Wu, Ho-ta Chu, Ting-xuan Liu, Yi-ping Yeh, Chieh Chang

Published in: Trials | Issue 1/2022

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Abstract

Background

Combining robotic therapy (RT) with task-oriented therapy is an emerging strategy to facilitate motor relearning in stroke rehabilitation. This study protocol will compare novel rehabilitation regimens that use bilateral RT as a priming technique to augment two task-oriented therapies: mirror therapy (MT) and bilateral arm training (BAT) with a control intervention: RT combined with impairment-oriented training (IOT).

Methods

This single-blind, randomized, comparative efficacy study will involve 96 participants with chronic stroke. Participants will be randomized into bilateral RT+MT, bilateral RT+BAT, and bilateral RT+IOT groups and receive 18 intervention sessions (90 min/day, 3 d/week for 6 weeks). The outcomes will include the Fugl-Meyer Assessment, Stroke Impact Scale version 3.0, Medical Research Council scale, Revised Nottingham Sensory Assessment, ABILHAND Questionnaire, and accelerometer and will be assessed at baseline, after treatment, and at the 3-month follow-up. Analysis of covariance and the chi-square automatic interaction detector method will be used to examine the comparative efficacy and predictors of outcome, respectively, after bilateral RT+MT, bilateral RT+BAT, and bilateral RT+IOT.

Discussion

The findings are expected to contribute to the research and development of robotic devices, to update the evidence-based protocols in postacute stroke care programs, and to investigate the use of accelerometers for monitoring activity level in real-life situations, which may in turn promote home-based practice by the patients and their caregivers. Directions for further studies and empirical implications for clinical practice will be further discussed in upper-extremity rehabilitation after stroke.

Trial registration

This trial was registered December 12, 2018, at www.clinicaltrials.gov (NCT03773653).
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Metadata
Title
Effects of robotic priming of bilateral arm training, mirror therapy, and impairment-oriented training on sensorimotor and daily functions in patients with chronic stroke: study protocol of a single-blind, randomized controlled trial
Authors
Yi-chen Lee
Yi-chun Li
Keh-chung Lin
Grace Yao
Ya-ju Chang
Ya-yun Lee
Chien-ting Liu
Wan-ling Hsu
Yi-hsuan Wu
Ho-ta Chu
Ting-xuan Liu
Yi-ping Yeh
Chieh Chang
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Stroke
Published in
Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-022-06498-0

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