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BMC Neurology
Published in: BMC Neurology 1/2011

Open Access 01-12-2011 | Case report

Stroke in hereditary hemorrhagic telangiectasia patients. New evidence for repeated screening and early treatment of pulmonary vascular malformations: two case reports

Authors: Espartaco Ribeiro, Julien Cogez, Emmanuel Babin, Fausto Viader, Gilles Defer

Published in: BMC Neurology | Issue 1/2011

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Abstract

Background

Paradoxical embolism due to pulmonary arteriovenous malformations is the main mechanism of brain infarction in patients with hereditary hemorrhagic telangiectasia. International Guidelines have recently been published to clarify the performance of screening tests and the effectiveness of treatment for pulmonary arteriovenous malformations.

Case Presentation

We present two cases of hereditary hemorrhagic telangiectasia patients of our hospital who experienced an acute stroke secondary to paradoxical embolism.

Conclusions

These two cases show that the guidelines must be followed to prevent the occurrence of ischemic stroke in patients with hereditary hemorrhagic telangiectasia, and that although they may be adequate in most cases, there are some patients who need a more personalized approach.
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Literature
1.
Kjeldsen AD, Vase P, Green A: Hereditary haemorrhagic telangiectasia: a population-based study of prevalence and mortality in Danish patients. J Intern Med. 1999, 245: 31-39. 10.1046/j.1365-2796.1999.00398.x.CrossRefPubMed
2.
Cottin V, Dupuis-Girod S, Lesca G, Cordier JF: Pulmonary Vascular Manifestations of Hereditary Hemorrhagic Telangiectasia (Rendu-Osler Disease). Respiration. 2007, 74: 361-378. 10.1159/000103205.CrossRefPubMed
3.
Cottin V, Plauchu H, Bayle JY, Barthelet M, Revel D, Cordier JF: Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia. Am J Respir Crit Care Med. 2004, 169: 994-1000. 10.1164/rccm.200310-1441OC.CrossRefPubMed
4.
Mager JJ, Overtoom TT, Blauw H, Lammers JW, Westermann CJ: Embolotherapy of pulmonary arteriovenous malformations: long-term results in 112 patients. J Vasc Interv Radiol. 2004, 15: 451-456.CrossRefPubMed
5.
Faughnan ME, Palda VA, Garcia-Tsao G, Geisthoff UW, McDonald J, Proctor DD, Spears J, Brown DH, Buscarini E, Chesnutt MS, Cottin V, Ganguly A, Gossage JR, Guttmacher AE, Hyland RH, Kennedy SJ, Korzenik J, Mager JJ, Ozanne AP, Piccirillo JF, Picus D, Plauchu H, Porteous MEM, Pyeritz RE, Ross DA, Sabba C, Swanson K, Terry P, Wallace MC, Westermann CJJ, White RI, Young LH, Zarrabeitia R: International Guidelines for the Diagnosis and Telangiectasia Management of Hereditary Hemorrhagic. J Med Genet. 2011, 48: 73-87. 10.1136/jmg.2009.069013.CrossRefPubMed
Metadata
Title
Stroke in hereditary hemorrhagic telangiectasia patients. New evidence for repeated screening and early treatment of pulmonary vascular malformations: two case reports
Authors
Espartaco Ribeiro
Julien Cogez
Emmanuel Babin
Fausto Viader
Gilles Defer
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2011
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-11-84

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