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Published in: Supportive Care in Cancer 12/2007

01-12-2007 | Original Article

Stress and long-term survivors of brain cancer

Authors: Stephen T. Keir, Jonas J. Swartz, Henry S. Friedman

Published in: Supportive Care in Cancer | Issue 12/2007

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Abstract

Introduction

Adult brain tumor patients are joining the ranks of cancer survivors in increasing numbers in the United States. As a result, health care providers are faced with new challenges to address the need for psychosocial support in this population.

Methods

Using the Perceived Stress Scale and the National Comprehensive Cancer Network’s Distress Thermometer, levels of stress and cancer-related items of concern were assessed in adult long-term survivors of brain cancer.

Results

Sixty-one percent of the sample population experienced elevated levels of stress. Scores were not significantly associated with age, gender, treatment status, or tumor grade. Long-term survivors were just as likely to report being stressed (χ 2 = 0.032, NS), while reporting fewer numbers of items of concern (5.02, SD = 3.509), compared to brain tumor patients diagnosed 18 months (M = 6.82, SD = 3.737, t = 2.467, p  0.05).

Discussion/conclusion

Despite their long-term survival status, long-term survivors of brain cancer continue to experience elevated levels of stress. Predictors of stress in this population are related to familial, emotional, and practical concerns. While the scientific community continues to examine the specific impact of stress on both the physical and mental outcomes of cancer patients, understanding the sources of stress within cancer populations is key in designing targeted interventions to help patients manage the stress associated with this disease.

Implications for brain tumor survivors

This study provides a better understanding of the unique needs of long-term survivors of brain cancer. An awareness of the sources and levels of stress experienced by this population could lead to the development of effective supportive care interventions to improve the quality of life of the survivor.
Literature
1.
go back to reference Academies IoMoN (2005) Cancer survivorship facts and figures. In: Institute of Medicine of the National Academies Academies IoMoN (2005) Cancer survivorship facts and figures. In: Institute of Medicine of the National Academies
2.
go back to reference Hewitt M et al (2005) From cancer patient to cancer survivor: lost in transition. National Academies, Washington, DC Hewitt M et al (2005) From cancer patient to cancer survivor: lost in transition. National Academies, Washington, DC
4.
8.
go back to reference Schmidinger M, Linzmayer L, Becherer A et al (2003) Psychometric- and quality-of-life assessment in long-term glioblastoma survivors. J Neurooncol 63(1):55–61PubMedCrossRef Schmidinger M, Linzmayer L, Becherer A et al (2003) Psychometric- and quality-of-life assessment in long-term glioblastoma survivors. J Neurooncol 63(1):55–61PubMedCrossRef
9.
go back to reference Deimling GT, Kahana B, Bowman KF, Schaefer ML (2002) Cancer survivorship and psychological distress in later life. Psychooncology 11(6):479–494PubMedCrossRef Deimling GT, Kahana B, Bowman KF, Schaefer ML (2002) Cancer survivorship and psychological distress in later life. Psychooncology 11(6):479–494PubMedCrossRef
10.
go back to reference Friedman HS, Szalavitz M (2003) What is “hope” for a patient with a deadly brain tumor? Cerebrum: The Dana Forum on Brain Science 5(3):7–18 Friedman HS, Szalavitz M (2003) What is “hope” for a patient with a deadly brain tumor? Cerebrum: The Dana Forum on Brain Science 5(3):7–18
11.
go back to reference Keir ST, Guill AB, Carter KE, Friedman HS (2006) Stress and intervention preferences of patients with brain tumors. Support Care Cancer 14(12):1213–1219PubMedCrossRef Keir ST, Guill AB, Carter KE, Friedman HS (2006) Stress and intervention preferences of patients with brain tumors. Support Care Cancer 14(12):1213–1219PubMedCrossRef
12.
go back to reference Edvardsson T, Ahlstrom G (2005) Illness-related problems and coping among persons with low-grade glioma. Psychooncology 14(9):728–737PubMedCrossRef Edvardsson T, Ahlstrom G (2005) Illness-related problems and coping among persons with low-grade glioma. Psychooncology 14(9):728–737PubMedCrossRef
13.
go back to reference Mainio A, Hakko H, Timonen M, Niemela A, Koivukangas J, Rasanen P (2005) Depression in relation to survival among neurosurgical patients with a primary brain tumor: a 5-year follow-up study. Neurosurgery 56(6):1234-1241; discussion 41–42PubMedCrossRef Mainio A, Hakko H, Timonen M, Niemela A, Koivukangas J, Rasanen P (2005) Depression in relation to survival among neurosurgical patients with a primary brain tumor: a 5-year follow-up study. Neurosurgery 56(6):1234-1241; discussion 41–42PubMedCrossRef
14.
go back to reference Zebrack BJ, Chesler MA (2002) Quality of life in childhood cancer survivors. Psychooncology 11(2):132–141PubMedCrossRef Zebrack BJ, Chesler MA (2002) Quality of life in childhood cancer survivors. Psychooncology 11(2):132–141PubMedCrossRef
15.
go back to reference Varni JW, Katz E (1997) Stress, social support and negative affectivity in children with newly diagnosed cancer: a prospective transactional analysis. Psychooncology 6(4):267–278PubMedCrossRef Varni JW, Katz E (1997) Stress, social support and negative affectivity in children with newly diagnosed cancer: a prospective transactional analysis. Psychooncology 6(4):267–278PubMedCrossRef
16.
go back to reference Stuber ML, Kazak AE, Meeske K et al (1997) Predictors of posttraumatic stress symptoms in childhood cancer survivors. Pediatrics 100(6):958–964PubMedCrossRef Stuber ML, Kazak AE, Meeske K et al (1997) Predictors of posttraumatic stress symptoms in childhood cancer survivors. Pediatrics 100(6):958–964PubMedCrossRef
17.
go back to reference Correa DD (2006) Cognitive functions in brain tumor patients. Hematol Oncol Clin North Am 20(6):1363–1376PubMedCrossRef Correa DD (2006) Cognitive functions in brain tumor patients. Hematol Oncol Clin North Am 20(6):1363–1376PubMedCrossRef
18.
go back to reference Stanton AL (2003) Psychosocial concerns and interventions for cancer survivors. J Clin Oncol 24(32):5132–5137CrossRef Stanton AL (2003) Psychosocial concerns and interventions for cancer survivors. J Clin Oncol 24(32):5132–5137CrossRef
19.
go back to reference Carlson LE, Bultz BD (2003) Benefits of psychosocial oncology care: Improved quality of life and medical cost offset. Health Qual Life Outcomes 1(1):8PubMedCrossRef Carlson LE, Bultz BD (2003) Benefits of psychosocial oncology care: Improved quality of life and medical cost offset. Health Qual Life Outcomes 1(1):8PubMedCrossRef
20.
go back to reference Carlson LE, Bultz BD (2003) Cancer distress screening. Needs, models, and methods. J Psychosom Res 55(5):403–409PubMedCrossRef Carlson LE, Bultz BD (2003) Cancer distress screening. Needs, models, and methods. J Psychosom Res 55(5):403–409PubMedCrossRef
21.
go back to reference Sellick SM, Crooks DL (1999) Depression and cancer: an appraisal of the literature for prevalence, detection, and practice guideline development for psychological interventions. Psychooncology 8(4):315–333PubMedCrossRef Sellick SM, Crooks DL (1999) Depression and cancer: an appraisal of the literature for prevalence, detection, and practice guideline development for psychological interventions. Psychooncology 8(4):315–333PubMedCrossRef
22.
go back to reference Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S (2001) The prevalence of psychological distress by cancer site. Psychooncology 10(1):19–28PubMedCrossRef Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S (2001) The prevalence of psychological distress by cancer site. Psychooncology 10(1):19–28PubMedCrossRef
23.
go back to reference Antoni MH, Lutgendorf SK, Cole SW et al (2006) The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 6(3):240–248PubMedCrossRef Antoni MH, Lutgendorf SK, Cole SW et al (2006) The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 6(3):240–248PubMedCrossRef
24.
go back to reference Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M (2003) Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol 157(5):415–423PubMedCrossRef Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M (2003) Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol 157(5):415–423PubMedCrossRef
25.
go back to reference Reiche EM, Nunes SO, Morimoto HK (2004) Stress, depression, the immune system, and cancer. Lancet Oncol 5(10):617–625PubMedCrossRef Reiche EM, Nunes SO, Morimoto HK (2004) Stress, depression, the immune system, and cancer. Lancet Oncol 5(10):617–625PubMedCrossRef
26.
go back to reference Ben-Eliyahu S (2003) The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain Behav Immun 17:S27–S36PubMedCrossRef Ben-Eliyahu S (2003) The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain Behav Immun 17:S27–S36PubMedCrossRef
27.
go back to reference Lutgendorf SK, Costanzo ES (2003) Psychoneuroimmunology and health psychology: an integrative model. Brain Behav Immun 17(4):225–232PubMedCrossRef Lutgendorf SK, Costanzo ES (2003) Psychoneuroimmunology and health psychology: an integrative model. Brain Behav Immun 17(4):225–232PubMedCrossRef
28.
go back to reference Lutgendorf SK, Cole S, Costanzo E et al (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9(12):4514–4521PubMed Lutgendorf SK, Cole S, Costanzo E et al (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9(12):4514–4521PubMed
29.
go back to reference Thaker PH, Han LY, Kamat AA et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12(8):939–944PubMedCrossRef Thaker PH, Han LY, Kamat AA et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12(8):939–944PubMedCrossRef
30.
go back to reference Cohen S, Kamarck T, Mermelstein R (1983) A global measure of perceived stress. J Health Soc Behav 24(4):385–396PubMedCrossRef Cohen S, Kamarck T, Mermelstein R (1983) A global measure of perceived stress. J Health Soc Behav 24(4):385–396PubMedCrossRef
31.
go back to reference Akizuki N, Yamawaki S, Akechi T, Nakano T, Uchitomi Y (2005) Development of an Impact Thermometer for use in combination with the Distress Thermometer as a brief screening tool for adjustment disorders and/or major depression in cancer patients. J Pain Symptom Manage 29(1):91–99PubMedCrossRef Akizuki N, Yamawaki S, Akechi T, Nakano T, Uchitomi Y (2005) Development of an Impact Thermometer for use in combination with the Distress Thermometer as a brief screening tool for adjustment disorders and/or major depression in cancer patients. J Pain Symptom Manage 29(1):91–99PubMedCrossRef
32.
go back to reference Dabrowski M, Boucher K, Ward JH et al (2007) Clinical experience with the NCCN distress thermometer in breast cancer patients. J Natl Compr Canc Netw 5(1):104–111PubMed Dabrowski M, Boucher K, Ward JH et al (2007) Clinical experience with the NCCN distress thermometer in breast cancer patients. J Natl Compr Canc Netw 5(1):104–111PubMed
33.
go back to reference Ransom S, Jacobsen PB, Booth-Jones M (2006) Validation of the Distress Thermometer with bone marrow transplant patients. Psychooncology 15(7):604–612PubMedCrossRef Ransom S, Jacobsen PB, Booth-Jones M (2006) Validation of the Distress Thermometer with bone marrow transplant patients. Psychooncology 15(7):604–612PubMedCrossRef
34.
go back to reference Vachon M (2006) Psychosocial distress and coping after cancer treatment. How clinicians can assess distress and which interventions are appropriate—what we know and what we don’t. Am J Nurs 106(3 Suppl):26–31PubMed Vachon M (2006) Psychosocial distress and coping after cancer treatment. How clinicians can assess distress and which interventions are appropriate—what we know and what we don’t. Am J Nurs 106(3 Suppl):26–31PubMed
Metadata
Title
Stress and long-term survivors of brain cancer
Authors
Stephen T. Keir
Jonas J. Swartz
Henry S. Friedman
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 12/2007
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-007-0292-1

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