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European Archives of Paediatric Dentistry

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01-12-2020 | Streptococci | Systematic Review

Topical fluoride-antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries: a systematic review and meta-analysis

Authors: A. Gupta, S. Sharda, Nishant, N. Shafiq, A. Kumar, A. Goyal

Published in: European Archives of Paediatric Dentistry | Issue 6/2020

Abstract

Purpose

To compare the effectiveness of topical fluoride—antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries among 1- to 16-year-old children.

Methods

PubMed, EbscoHost, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials were searched for randomised controlled trials. The trials should have assessed the caries-preventive effectiveness of topical fluoride-antibacterial agent (Povidone Iodine/Chlorhexidine/Xylitol/Triclosan/Cetylpyridinium Chloride) combined therapy versus topical fluoride monotherapy among children. Out of 3475 records that were screened, full text of 41 articles was assessed for potential inclusion. Sixteen trials that fulfilled the eligibility criteria were subjected to qualitative synthesis. The risk of bias was assessed using the Cochrane Collaboration’s tool. Continuous data from nine trials were pooled using Inverse Variance test in meta-analysis function of Review Manager (version 5.4). GRADE approach was used to analyse the certainty of evidence. Statistical heterogeneity was quantified using the I² statistic. A p-value of < 0.05 was considered as statistically significant.

Results

With respect to the caries increment, combined therapy showed superior caries-preventive effectiveness than topical fluoride monotherapy [SMD − 0.12, 95% CI (− 0.2 to − 0.04), p = 0.004; (I² = 20%, p = 0.29)]. No significant difference was noted between the two groups for the post-intervention salivary S mutans count [SMD − 0.11, 95% CI (− 0.33 to 0.1), p = 0.3; (I² = 0%, p = 0.77)].

Conclusion

The pooled analysis indicates towards an added benefit of topical fluoride-antibacterial agent combined therapy over topical fluoride monotherapy in preventing dental caries incidence among children. However, the results may be interpreted with caution since the evidence generated is of low certainty and is driven by two studies on Xylitol, thus it demands further good quality trials.

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Title: Topical fluoride-antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries: a systematic review and meta-analysis
Authors: A. Gupta
S. Sharda
Nishant
N. Shafiq
A. Kumar
A. Goyal
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keywords: Streptococci
Caries
Published in: European Archives of Paediatric Dentistry / Issue 6/2020
Print ISSN: 1818-6300
Electronic ISSN: 1996-9805
DOI: https://doi.org/10.1007/s40368-020-00561-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Topical fluoride-antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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