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American Journal of Clinical Dermatology

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01-08-2004 | Leading Article

Stratum Corneum pH in Atopic Dermatitis

Impact on Skin Barrier Function and Colonization with Staphylococcus Aureus

Authors: Dr Frank Rippke, Volker Schreiner, Thomas Doering, Howard I. Maibach

Published in: American Journal of Clinical Dermatology | Issue 4/2004

Abstract

Recent studies have provided new insights into the occurrence, causes, and pathogenetic consequences of changes in the skin pH in atopic dermatitis, particularly with respect to skin barrier function and colonization with Staphylococcus aureus. Growing evidence suggests an impaired release of proton donors, such as amino acids, urocanic acid, and lactic acid, to the stratum corneum in atopic dermatitis, as a result of reductions in filaggrin proteolysis and sweat secretion. In addition, an impaired formation of free fatty acids from sebaceous lipids and epidermal phospholipids seems to be involved. Because both lipid organization and lipid metabolism in the stratum corneum requires an acidic pH, these alterations might contribute to the disturbance of skin barrier function observed in atopic dermatitis. Furthermore, bacterial growth and virulence of S. aureus, as well as defensive host mechanisms, have increasingly been delineated as pH dependent, giving rise to a new understanding of the pathophysiology underlying increased skin colonization seen in atopic dermatitis.

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Title: Stratum Corneum pH in Atopic Dermatitis
Impact on Skin Barrier Function and Colonization with Staphylococcus Aureus
Authors: Dr Frank Rippke
Volker Schreiner
Thomas Doering
Howard I. Maibach
Publication date: 01-08-2004
Publisher: Springer International Publishing
Published in: American Journal of Clinical Dermatology / Issue 4/2004
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.2165/00128071-200405040-00002

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Stratum Corneum pH in Atopic Dermatitis

Impact on Skin Barrier Function and Colonization with Staphylococcus Aureus

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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