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01-09-2009 | Review

Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis

Authors: Darren Bridgewater, Norman D. Rosenblum

Published in: Pediatric Nephrology | Issue 9/2009

Abstract

Branching morphogenesis, defined as the growth and branching of epithelial tubules, is a fundamental developmental process involved in the formation of a variety of mammalian tissues, including the kidney. Defective renal branching may result in a number of clinically relevant abnormalities, including renal agenesis, renal dysplasia, multiplex kidneys, and hypertension. In this review we describe the morphological events that generate the characteristic tree-like structure of the mammalian collecting system. We also highlight new knowledge related to both established and novel signaling systems that are important for stimulating and inhibiting branching morphogenesis.

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Title: Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis
Authors: Darren Bridgewater
Norman D. Rosenblum
Publication date: 01-09-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-008-1048-y

At a glance: The STEP trials

Springer Medicine

Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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