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Open Access 01-12-2010 | Research

Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma

Authors: Koji Kawaguchi, Kengo Sato, Akihisa Horie, Susumu Iketani, Hiroyuki Yamada, Yasunori Nakatani, Junichi Sato, Yoshiki Hamada

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

The aim of this study is to examine the effect of stereotactic radiosurgery (SRS) in the treatment of advanced, recurrent lesions for head and neck carcinoma both with and without lymph node involvement.

Methods

Between April 2006 and July 2007, 22 patients (mean age 67 years) with advanced, recurrent head and neck carcinoma were treated with stereotactic radiosurgery. All of the patients except one had biopsy confirmed disease prior to stereotactic radiosurgery. Patients included 3 rT2, 8 rT3, and 9 rT4; 8 of the patients had lymph node metastases. Marginal SRS doses were 20-42 Gy delivered in two to five fractions. Starting one month after SRS, all patients received S-1 oral chemotherapy for one year.

Results

At an overall median follow-up of 24 months (range, 4-39 months), for the 14 locally recurrent patients without lymph node metastases, 9 patients (64.3%) had a complete response (CR), 1 patient (7.1%) had a partial response (PR), 1 patient (7.1%) had stable disease (SD), and 3 patients (21.4%) had progressive disease (PD). For the 8 patients with lymph node metastases, 1 patient with a single retropharyngeal (12.5%) had CR; the remaining 7 patients (87.5%) all progressed. Nine patients have died from their cancer. The overall actuarial 2-year survival for the patients with and without lymph node metastases is 12.5% and 78.6%, respectively.

Conclusions

These results show the benefit of stereotactic radiosurgery salvage treatment for advanced, recurrent lesions, without lymph node metastases in previously irradiated head and neck cancer.

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Title: Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma
Authors: Koji Kawaguchi
Kengo Sato
Akihisa Horie
Susumu Iketani
Hiroyuki Yamada
Yasunori Nakatani
Junichi Sato
Yoshiki Hamada
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-51

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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