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01-12-2019 | Topic Paper

Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment

Authors: C. Leigh Moyer, Ryan Phillips, Matthew P. Deek, Noura Radwan, Ashley E. Ross, Emmanuel S. Antonarakis, Diane Reyes, Jean Wright, Stephanie A. Terezakis, Daniel Y. Song, Curtiland DeVille, Patrick C. Walsh, Theodore L. DeWeese, Michael Carducci, Edward M. Schaeffer, Kenneth J. Pienta, Mario Eisenberger, Phuoc T. Tran

Published in: World Journal of Urology | Issue 12/2019

Abstract

Purpose

Local ablative treatment to oligometastatic patients can result in long-term disease-free survival in some cancer patients. The importance of this treatment paradigm in prostate cancer is a rapidly evolving field. Herein, we report on the safety and preliminary clinical outcomes of a modern cohort of oligometastatic prostate cancer (OPC) patients treated with consolidative stereotactic ablative radiation (SABR).

Methods

Records of men with OPC who underwent consolidative SABR at our institution were reviewed. SABR was delivered in 1–5 fractions of 5–18 Gray. Kaplan–Meier estimates of local progression-free survival (LPFS), biochemical progression-free survival (bPFS; PSA nadir + 2), distant progression-free survival (DPFS), and time-to-next intervention (TTNI) were calculated.

Results

In total, 66 OPC patients were identified with consolidative SABR delivered to 134 metastases: 89 bone, 40 nodal, and 5 viscera. The majority of men (49/66) had hormone-sensitive prostate cancer (HSPC). Crude grade 1 and 2 acute toxicities were 36% and 11%, respectively, with no ≥ grade 3 toxicity. At 1 year, LPFS was 92% and bPFS and DPFS were 69%. Of the 18 men with HSPC who had deferred hormone therapy , 11 (56%) remain disease free following SABR (1-year ADT-FS was 78%). In 17 castration-resistant men, 11 had > 50% prostate-specific antigen (PSA) declines with 1-year TTNI of 30%.

Conclusions

Consolidative SABR in OPC is feasible and well tolerated. The heterogeneity and small size of our series limit extrapolation of clinically meaningful outcomes following consolidative SABR in OPC, but our preliminary data suggest that this approach warrants continued prospective study.

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Title: Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment
Authors: C. Leigh Moyer
Ryan Phillips
Matthew P. Deek
Noura Radwan
Ashley E. Ross
Emmanuel S. Antonarakis
Diane Reyes
Jean Wright
Stephanie A. Terezakis
Daniel Y. Song
Curtiland DeVille
Patrick C. Walsh
Theodore L. DeWeese
Michael Carducci
Edward M. Schaeffer
Kenneth J. Pienta
Mario Eisenberger
Phuoc T. Tran
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 12/2019
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-018-2477-2

2024 ASCO Annual Meeting

Springer Medicine

Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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