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Alzheimer's Research & Therapy
Published in: Alzheimer's Research & Therapy 5/2012

01-12-2012 | Review

Stem cell models of Alzheimer's disease and related neurological disorders

Author: Frederick J Livesey

Published in: Alzheimer's Research & Therapy | Issue 5/2012

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Abstract

Human models of Alzheimer's disease (AD) have the potential to complement existing animal models for carrying out functional studies of AD pathogenesis and the development of novel therapies. An effective human cellular model of AD would use the appropriate cell types and ideally neural circuits affected by the disease, would develop relevant pathology and would do so in a reproducible manner over a timescale short enough for practical use. A pressing question for the usefulness of this approach is whether neurological diseases that take decades to become manifest in humans can be successfully modelled over a reasonable timescale. We discuss here whether these models can do more than simply replicate what is already known about AD, and evaluate some of their potentially unique advantages.
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Metadata
Title
Stem cell models of Alzheimer's disease and related neurological disorders
Author
Frederick J Livesey
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Alzheimer's Research & Therapy / Issue 5/2012
Electronic ISSN: 1758-9193
DOI
https://doi.org/10.1186/alzrt147

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