Skip to main content
Top
Published in: Indian Journal of Surgical Oncology 3/2012

01-09-2012 | Review Article

Statistics for Surgeons – Understanding Survival Analysis

Author: Girdhar Gopal Agarwal

Published in: Indian Journal of Surgical Oncology | Issue 3/2012

Login to get access

Abstract

Survival data stand out as a special statistical field. This paper tries to describe what survival data is and what makes it so special. Survival data concerns times to some events. A key point is the successive observation of time, which on the one hand leads to sometimes not being observed so that all that is known is that they exceed some given times (censoring), and on the other hand implies that predictions regarding the future course should be conditional on the present status (truncation). In the simplest case, this condition is that the individual is alive. The successive conditioning makes the hazard function, which describes the probability of an event happening during a short interval given that the individual is alive today, the most relevant concept. Here we discuss parametric as well as non-parametric methods. Examples are presented in a way that can be followed without the help of computers.
Literature
1.
go back to reference Cox DR, Oakes D (1984) Analysis of survival data. Chapman and Hall, New York Cox DR, Oakes D (1984) Analysis of survival data. Chapman and Hall, New York
2.
go back to reference Armitage P, Gehan EA (1974) Statistical methods for the identification and use of prognostic factors. Int J Cancer 13:16–35PubMedCrossRef Armitage P, Gehan EA (1974) Statistical methods for the identification and use of prognostic factors. Int J Cancer 13:16–35PubMedCrossRef
3.
go back to reference Pocock SJ, Gore SM, Kerr GM (1982) Long term survival analysis: the curability of cancer. Stat Med 1:93–104PubMedCrossRef Pocock SJ, Gore SM, Kerr GM (1982) Long term survival analysis: the curability of cancer. Stat Med 1:93–104PubMedCrossRef
4.
go back to reference Abdi EA, Hanson J, McPherson TA (1987) Adjuvant chemoimmunotheapy after regional lymphadenectomy for malignant melanoma. Am J Clin Oncol 10:117–122PubMedCrossRef Abdi EA, Hanson J, McPherson TA (1987) Adjuvant chemoimmunotheapy after regional lymphadenectomy for malignant melanoma. Am J Clin Oncol 10:117–122PubMedCrossRef
5.
go back to reference Bonadonna G et al (1976) Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294:405–410PubMedCrossRef Bonadonna G et al (1976) Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294:405–410PubMedCrossRef
6.
go back to reference Armitage P (1959) The comparison of survival curves. Journal of the Royal Statistical Society, Series A 122:279–300CrossRef Armitage P (1959) The comparison of survival curves. Journal of the Royal Statistical Society, Series A 122:279–300CrossRef
7.
go back to reference Soler-Vila H, Kasl SV, Jones BA (2005) Cancer-specific beliefs and survival: a population- based study of African-American and white breast cancer patients. Cancer Causes Control 16:105–114PubMedCrossRef Soler-Vila H, Kasl SV, Jones BA (2005) Cancer-specific beliefs and survival: a population- based study of African-American and white breast cancer patients. Cancer Causes Control 16:105–114PubMedCrossRef
8.
go back to reference Brookmeyer R, Goedert JJ (1989) Censoring in an epidemic with an application to hemophilia-associated AIDS. Biometrics 45:325–335PubMedCrossRef Brookmeyer R, Goedert JJ (1989) Censoring in an epidemic with an application to hemophilia-associated AIDS. Biometrics 45:325–335PubMedCrossRef
9.
go back to reference Cohen Ac Jr (1963) Progressively censored sample in life testing. Technometrics 3:535–541CrossRef Cohen Ac Jr (1963) Progressively censored sample in life testing. Technometrics 3:535–541CrossRef
10.
go back to reference Ederer F, Axtell LM, Cutler SJ (1961) The relative survival rate- a statistical methodology. National Cancer Institute Monographs 6:101–121 Ederer F, Axtell LM, Cutler SJ (1961) The relative survival rate- a statistical methodology. National Cancer Institute Monographs 6:101–121
11.
go back to reference Breslow NE, Day NE (1980) Statistical Methods in Cancer Research, Vol 1-The Analysis of Case–control Studies. International Agency for Research on Cancer, Lyon Breslow NE, Day NE (1980) Statistical Methods in Cancer Research, Vol 1-The Analysis of Case–control Studies. International Agency for Research on Cancer, Lyon
12.
go back to reference Nelson W (1972) Theory and applications of hazard plotting for censored failure data. Technometrics 14:945–966CrossRef Nelson W (1972) Theory and applications of hazard plotting for censored failure data. Technometrics 14:945–966CrossRef
13.
go back to reference Nadas A (1970) On proportional hazard functions. Technometrics 12:413–416CrossRef Nadas A (1970) On proportional hazard functions. Technometrics 12:413–416CrossRef
14.
go back to reference Tarone RE, Ware J (1977) On distribution-free tests for equality of survival distributions. Biometrics 64:156–160CrossRef Tarone RE, Ware J (1977) On distribution-free tests for equality of survival distributions. Biometrics 64:156–160CrossRef
15.
go back to reference Fleming TR, Harrington DP, O’Brien PC (1984) Design for group sequential tests. Control Clin Trials 5:348–361PubMedCrossRef Fleming TR, Harrington DP, O’Brien PC (1984) Design for group sequential tests. Control Clin Trials 5:348–361PubMedCrossRef
Metadata
Title
Statistics for Surgeons – Understanding Survival Analysis
Author
Girdhar Gopal Agarwal
Publication date
01-09-2012
Publisher
Springer-Verlag
Published in
Indian Journal of Surgical Oncology / Issue 3/2012
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-012-0149-z

Other articles of this Issue 3/2012

Indian Journal of Surgical Oncology 3/2012 Go to the issue

Original Article

Thyroid Incidentaloma