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01-02-2008 | Correspondence

Statins, Regulatory T Cells and Amyotrophic Lateral Sclerosis

Authors: Mark R. Goldstein, Luca Mascitelli, Francesca Pezzetta

Published in: Drug Safety | Issue 2/2008

Excerpt

The interesting paper by Edwards et al.[1] reports a disproportionate increase in the incidence of amyotrophic lateral sclerosis (ALS) or an ALS-like syndrome with HMG-CoA reductase inhibitor (‘statin’) therapy. Recent data shed light on the mechanisms by which this may occur. This needs our attention, given the widespread and expanding use of statins at high doses.[2] …

Edwards IR, Star K, Kiuru A. Statins, neuromuscular degenerative disease and an amyotrophic lateral sclerosis-like syndrome: an analysis of individual case safety reports from Vigibase. Drug Saf 2007; 30(6): 515–25PubMedCrossRef

LaRosa JC. Low-density lipoprotein cholesterol reduction: the end is more important than the means. Am J Cardiol 2007; 100: 240–2PubMedCrossRef

Mausner-Fainberg K, Luboshits G, Mor A, et al. The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells. Atherosclerosis. Epub 2007 Sept 10

Mallat Z, Ait-Oufella H, Tedgui A. Regulatory T cell responses: potential role in the control of atherosclerosis. Curr Opin Lipidol 2005; 16: 518–24PubMedCrossRef

Kipnis J, Mizrahi T, Hauben E, et al. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci 2002; 99: 15620–5PubMedCrossRef

Pacheco R, Gallart T, Lluis C, et al. Role of glutamate on T-cell mediated immunity. J Neuroimmunol 2007; 185: 9–19PubMedCrossRef

Kipnis J, Yoles E, Mizrahi T, et al. Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. J Neuroimmunol 2002; 130: 78–85PubMedCrossRef

Schwartz M, Kipnis J. A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostatis. Trends in Pharm Sci 2004; 25: 407–12CrossRef

Title: Statins, Regulatory T Cells and Amyotrophic Lateral Sclerosis
Authors: Mark R. Goldstein
Luca Mascitelli
Francesca Pezzetta
Publication date: 01-02-2008
Publisher: Springer International Publishing
Published in: Drug Safety / Issue 2/2008
Print ISSN: 0114-5916
Electronic ISSN: 1179-1942
DOI: https://doi.org/10.2165/00002018-200831020-00007

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Statins, Regulatory T Cells and Amyotrophic Lateral Sclerosis

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