Statins in patients with sepsis and ARDS: is it over? No

Excerpt

Sepsis and ARDS are diverse syndromes where the host response to an insult results in varied clinical manifestations and associated organ dysfunction. While the overwhelming impression of over 30 years of sepsis research is that nothing new seems to work, clinical outcomes have improved over time [1, 2] with the inference that we must be doing something right. Particularly for sepsis, but the principles apply no less to ARDS, the mainstay of therapy involves resuscitation, managing infection (with antibiotics and through source control), supportive care and finally adjunctive therapy [3]. It is the last of these that has led to the most disappointment [4]. …