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BMC Oral Health
Published in: BMC Oral Health 1/2008

Open Access 01-12-2008 | Research article

Statin use is associated with fewer periodontal lesions: A retrospective study

Authors: Otso Lindy, Kimmo Suomalainen, Marja Mäkelä, Seppo Lindy

Published in: BMC Oral Health | Issue 1/2008

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Abstract

Background

Inflammatory processes are considered to participate in the development of cardiovascular disease (CVD). Statins have been used successfully in the prevention and treatment of coronary heart disease. Chronic periodontitis has been suggested to contribute to CVD. The aim of this study was to examine the association of statin use and clinical markers of chronic periodontitis.

Methods

Periodontal probing pocket depth (PPD) values were collected from dental records of 100 consecutive adult patients referred to a university dental clinic for treatment of advanced chronic periodontitis. A novel index, Periodontal Inflammatory Burden Index (PIBI), was derived from the PPD values to estimate systemic effects of periodontitis.

Results

Periodontitis patients taking statins had a 37% lower number of pathological periodontal pockets than those without statin medication (P = 0.00043). PIBI, which combines and unifies the data on PPD, was 40% smaller in statin using patients than in patients without statin (P = 0.00069). PIBI of subjects on simvastatin and atorvastatin both differed significantly from patients without statin and were on the same level. The subjects' number of teeth had no effect on the results

Conclusion

Patients on statin medication exhibit fewer signs of periodontal inflammatory injury than subjects without the statin regimen. PIBI provides a tool for monitoring inflammatory load of chronic periodontitis. The apparent beneficial effects of statins may in part be mediated by their pleiotropic anti-inflammatory effect on periodontal tissue.
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Literature
1.
Endo A, Kuroda M, Tanzawa K: Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett. 1976, 72: 323-6. 10.1016/0014-5793(76)80996-9.CrossRefPubMed
2.
Scandinavian Simvastatin Survival Study Group: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994, 344: 1383-9. 10.1016/S0140-6736(94)90566-5.
3.
Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995, 333: 1301-7. 10.1056/NEJM199511163332001.CrossRefPubMed
4.
Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, ASCOT investigators: Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. 2003, 361: 1149-1158. 10.1016/S0140-6736(03)12948-0.CrossRefPubMed
5.
Vaughan CJ, Murphy MB, Buckley BM: Statins do more than just lower cholesterol. Lancet. 1996, 348: 1079-1082. 10.1016/S0140-6736(96)05190-2.CrossRefPubMed
6.
Kwak B, Mulhaupt F, Myit S, Mach F: Statins as a newly recognized type of immunomodulator. Nat Med. 2000, 6: 1399-1402. 10.1038/82219.CrossRefPubMed
7.
Liao JK, Laufs U: Pleiotropic effects of statins. Ann Rev Pharmacol Toxicol. 2005, 45: 89-118. 10.1146/annurev.pharmtox.45.120403.095748.CrossRef
8.
Lindy S, Turto H, Uitto J, Helin P, Lorenzen I: Injury and repair in arterial tissue in the rabbit. Analysis of DNA, RNA, hydroxyproline, and lactate dehydrogenase in experimental arteriosclerosis. Circ Res. 1972, 30: 123-130.CrossRefPubMed
9.
Ross R, Glomset JA: The pathogenesis of atherosclerosis (first of two parts). N Engl J Med. 1976, 295: 369-377.CrossRefPubMed
10.
Ross R, Glomset JA: The pathogenesis of atherosclerosis (second of two parts). N Engl J Med. 1976, 295: 420-425.CrossRefPubMed
11.
Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005, 352: 1685-1695. 10.1056/NEJMra043430.CrossRefPubMed
12.
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997, 336: 973-979. 10.1056/NEJM199704033361401. Erratum in: N Engl J Med 1997, 337: 356.CrossRefPubMed
13.
Albandar JM, Rams TE: Global epidemiology of periodontal diseases: an overview. Periodontology 2000. 2002, 29: 7-10. 10.1034/j.1600-0757.2002.290101.x.CrossRefPubMed
14.
Southerland JH, Taylor GW, Moss K, Beck JD, Offenbacher S: Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease. Periodontol 2000. 2006, 40: 130-143. 10.1111/j.1600-0757.2005.00138.x.CrossRefPubMed
15.
Pihlstrom BL, Michalowicz BS, Johnson NW: Periodontal diseases. Lancet. 2005, 366: 1809-1820. 10.1016/S0140-6736(05)67728-8.CrossRefPubMed
16.
Deliargyris EN, Madianos PN, Kadoma W, Marron I, Smith SC, Beck JD, Offenbacher S: Periodontal disease in patients with acute myocardial infarction: prevalence and contribution to elevated C-reactive protein levels. Am Heart J. 2004, 147: 1005-1009. 10.1016/j.ahj.2003.12.022.CrossRefPubMed
17.
D'Aiuto F, Ready D, Tonetti MS: Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res. 2004, 39: 236-241. 10.1111/j.1600-0765.2004.00731.x.CrossRefPubMed
18.
D'Aiuto F, Parkar M, Nibali L, Suvan J, Lessem J, Tonetti MS: Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am Heart J. 2006, 151: 977-984. 10.1016/j.ahj.2005.06.018.CrossRefPubMed
19.
Nibali L, D'Aiuto F, Griffiths G, Patel K, Suvan J, Tonetti MS: Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study. J Clin Periodontol. 2007, 34: 931-937. 10.1111/j.1600-051X.2007.01133.x.CrossRefPubMed
20.
Silness J, Löe H: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964, 22: 121-135. 10.3109/00016356408993968.CrossRefPubMed
21.
Ainamo J, Barmes D, Beagrie G, Cutress T, Martin J, Sardo-Infirri J: Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN). Int Dent J. 1982, 32: 281-291.PubMed
22.
Armitage GC: The complete periodontal examination. Periodontology 2000. 2004, 34: 22-33. 10.1046/j.0906-6713.2002.003422.x.CrossRefPubMed
23.
Armitage GC: Periodontal diagnosis and classification of periodontal diseases. Periodontology 2000. 2004, 34: 9-21. 10.1046/j.0906-6713.2002.003421.x.CrossRefPubMed
24.
25.
26.
27.
Albandar JM: Periodontal diseases in North America. Periodontol 2000. 2002, 29: 31-69. 10.1034/j.1600-0757.2002.290103.x.CrossRefPubMed
28.
Booth GL, Kapral MK, Fung K, Tu JV: Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet. 2006, 368: 29-36. 10.1016/S0140-6736(06)68967-8.CrossRefPubMed
29.
Hobdell MH, Oliviera ER, Bautista R, Myburgh NG, Lalloo R, Narendran S, Johnson NW: Oral diseases and socio-economic status (SES). Br Dent J. 2003, 194: 91-96. 10.1038/sj.bdj.4809882.CrossRefPubMed
30.
Albert MA, Glynn RJ, Buring J, Ridker PM: Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation. 2006, 114: 2619-2626. 10.1161/CIRCULATIONAHA.106.660043.CrossRefPubMed
31.
Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B: Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J. 2003, 24: 2099-107. 10.1016/j.ehj.2003.09.016.CrossRefPubMed
32.
Paquette DW, Brodala N, Nichols TC: Cardiovascular disease, inflammation, and periodontal infection. Periodontol 2000. 2007, 44: 113-126. 10.1111/j.1600-0757.2006.00196.x.CrossRefPubMed
33.
Mealey BL: Periodontal disease and diabetes: A two-way street. J Am Dent Assoc. 2006, 137 (Suppl 2): 26S-31S.CrossRefPubMed
34.
Offenbacher S, Boggess KA, Murtha AP, Jared HL, Lieff S, McKaig RG, Mauriello SM, Moss KL, Beck JD: Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol. 2006, 107: 29-36.CrossRefPubMed
35.
Paunio K, Impivaara O, Tiekso J, Maki J: Missing teeth and ischaemic heart disease in men aged 45–64 years. Eur Heart J. 1993, 14 (Suppl K): 54-56.PubMed
36.
Ajwani S, Mattila KJ, Närhi TO, Tilvis RS, Ainamo A: Oral health status, C-reactive protein and mortality–a 10 year follow-up study. Gerodontology. 2003, 20: 32-40. 10.1111/j.1741-2358.2003.00032.x.CrossRefPubMed
37.
Völzke H, Schwahn C, Hummel A, Wolff B, Kleine V, Robinson DM, Dahm JB, Felix SB, John U, Kocher T: Tooth loss is independently associated with the risk of acquired aortic valve sclerosis. Am Heart J. 2005, 150: 1198-1203. 10.1016/j.ahj.2005.01.004.CrossRefPubMed
38.
Meurman JH, Sanz M, Janket SJ: Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med. 2004, 15: 403-413.CrossRefPubMed
39.
Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J: Treatment of periodontitis and endothelial function. N Engl J Med. 2007, 356: 911-920. 10.1056/NEJMoa063186.CrossRefPubMed
40.
Jones PH, Davidson MH, Stein EA, Bays HE, McKenney JM, Miller E, Cain VA, Blasetto JW, STELLAR Study Group: Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial). Am J Cardiol. 2003, 92: 152-160. 10.1016/S0002-9149(03)00530-7.CrossRefPubMed
Metadata
Title
Statin use is associated with fewer periodontal lesions: A retrospective study
Authors
Otso Lindy
Kimmo Suomalainen
Marja Mäkelä
Seppo Lindy
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2008
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/1472-6831-8-16

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