Top

Osteoporosis International

Published in:

Open Access 01-09-2017 | Letter

Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies

Authors: A. Donzelli, A. Battaggia, A. Schivalocchi

Published in: Osteoporosis International | Issue 9/2017

Excerpt

Dear Editor, …

An T, Hao J, Sun S, Li R, Yang M, Cheng G, Zou M. Efficacy of statins for osteoporosis: a systematic review and meta-analysis. Osteoporos Int 28:47–57. doi:10.1007/s00198-016-3844-8

Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J et al (2006) A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 333(7557):15CrossRefPubMedPubMedCentral

Curtis JR, Larson JC, Delzell E et al (2011) Placebo adherence, clinical outcomes, and mortality in the women's health initiative randomized hormone therapy trials. Med Care 49(5):427–435CrossRefPubMedPubMedCentral

Curtis JR, Delzell E, Chen L, Brookhart MA, Cadarette SM, Chlebowski R et al (2011) The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial. J Bone Miner Res 26(4):683–688CrossRefPubMed

Dormuth CR, Patrick AR, Shrank WH, Wright JM, Glynn RJ, Sutherland J et al (2009) Statin adherence and risk of accidents: a cautionary tale. Circulation 119(15):2051–2057CrossRefPubMedPubMedCentral

Reid IR, Hague W, Emberson J, Baker J, Tonkin A, Hunt D et al (2001) Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease 357(9255):509–512

Peña JM, Aspberg S, MacFadyen J, Glynn RJ, Solomon DH, Ridker PM (2015) Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial. JAMA Intern Med 175(2):171–177CrossRefPubMedPubMedCentral

Chen ZG, Cai HJ, Jin X, Lu JH, Wang J, Fang NY (2014) Effects of atorvastatin on bone mineral density (BMD) and bone metabolism in elderly males with osteopenia and mild dyslipidemia: a 1-year randomized trial. Arch Gerontol Geriatr 59(3):515–521CrossRefPubMed

Rejnmark L, Buus NH, Vestergaard P, Heickendorff L, Andreasen F, Larsen ML et al (2004) Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. J Bone Miner Res 19(5):737–744CrossRefPubMed

Title: Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies
Authors: A. Donzelli
A. Battaggia
A. Schivalocchi
Publication date: 01-09-2017
Publisher: Springer London
Published in: Osteoporosis International / Issue 9/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-017-4069-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 9/2017

Effects of a 20-week high-intensity strength and sprint training program on tibial bone structure and strength in middle-aged and older male sprint athletes: a randomized controlled trial

Excess of all-cause mortality after a fracture in type 2 diabetic patients: a population-based cohort study

Sustainable affordability of Otago exercise in the US healthcare system: response to Liu et al.

FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry

Determinants of bone mineral density in young Australian women; results from the Safe-D study

Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation