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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-05-2016 | Retinal Disorders

Static characteristics and dynamic functionality of retinal vessels in longer eyes with or without pathologic myopia

Authors: Carlo La Spina, Federico Corvi, Francesco Bandello, Giuseppe Querques

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2016

Abstract

Purpose

To analyze major retinal vessels in eyes with high myopia by means of the Dynamic Vessel Analyzer (DVA) in order to gather insight on retinal vascular functionality and better understand why these eyes are resistant to diabetes-related changes.

Methods

A total of 20 high-myopia eyes with pathologic myopia, 20 high-myopia eyes without pathologic myopia and 20 age- and sex-matched control subjects (without pathologic myopia) were included and compared.

Results

Dynamic analysis showed mean arterial dilation of 2.44 ± 1.59 % in high-myopia eyes with pathologic myopia, 2.67 ± 1.17 in high-myopia without pathologic myopia eyes, and 3.28 ± 1.46 % in healthy eyes. Mean venous dilation was 3.45 ± 1.82 %, 3.57 ± 1.72, and 4.45 ± 2.72 % respectively. Static analysis in high myopia eyes with pathologic myopia showed a mean central retinal artery equivalent (CRAE) of 171.6 ± 24.3, a mean central retinal vein equivalent (CRVE) of 199.5 ± 27.73, and a mean arteriovenous ratio (AVR) of 0.86 ± 0.01. In patients with high myopia without pathologic myopia, we found a mean CRAE of 173 ± 21.6, a mean CRVE of 198.2 ± 18.8, and a mean AVR of 0.87 ± 0.1. In control subjects, mean CRAE was 190.3 ± 11.93, mean was CRVE 215.7 ± 13.30, and mean AVR was 0.88 ± 0.04.

Conclusions

Static and dynamic tests revealed that in high-myopia eyes, the vessels at the retinal posterior pole have reduced diameter, but are functionally comparable to control subjects. This supports the hypothesis of reduced oxygen consumption in high-myopia eyes.

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Title: Static characteristics and dynamic functionality of retinal vessels in longer eyes with or without pathologic myopia
Authors: Carlo La Spina
Federico Corvi
Francesco Bandello
Giuseppe Querques
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3122-z

At a glance: The STEP trials

Springer Medicine

Static characteristics and dynamic functionality of retinal vessels in longer eyes with or without pathologic myopia

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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