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Brain Structure and Function
Published in: Brain Structure and Function 4/2005

01-11-2005 | Original article

Standard atlas space for C57BL/6J neonatal mouse brain

Authors: Erh-Fang Lee, Russell E. Jacobs, Ivo Dinov, Alex Leow, Arthur W. Toga

Published in: Brain Structure and Function | Issue 4/2005

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Abstract

A standard atlas space with stereotaxic co-ordinates for the postnatal day 0 (P0) C57BL/6J mouse brain was constructed from the average of eight individual co-registered MR image volumes. Accuracy of registration and morphometric variations in structures between subjects were analyzed statistically. We also applied this atlas coordinate system to data acquired using different imaging protocols as well as to a high-resolution histological atlas obtained from separate animals. Mapping accuracy in the atlas space was examined to determine the applicability of this atlas framework. The results show that the atlas space defined here provides a stable framework for image registration for P0 normal mouse brains. With an appropriate feature-based co-registration strategy, the probability atlas can also provide an accurate anatomical map for images acquired using invasive imaging methods. The atlas templates and the probability map of the anatomical labels are available at http://​www.​loni.​ucla.​edu/​MAP/​.
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Metadata
Title
Standard atlas space for C57BL/6J neonatal mouse brain
Authors
Erh-Fang Lee
Russell E. Jacobs
Ivo Dinov
Alex Leow
Arthur W. Toga
Publication date
01-11-2005
Publisher
Springer-Verlag
Published in
Brain Structure and Function / Issue 4/2005
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-005-0048-y

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