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European Archives of Oto-Rhino-Laryngology

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01-01-2011 | Head and Neck

Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose

Authors: Görkem Eskiizmir, Gülsüm Gençoğlan, Peyker Temiz, Zafer Hirçin, Aylin Ermertcan

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2011

Abstract

The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose.

Staples M, Marks R, Giles G (1998) Trends in the incidence of non-melanocytic skin cancer (NMSC) treated in Australia 1985–1995: are primary prevention programs starting to have an effect? Int J Cancer 78:144–148CrossRefPubMed

Harris KB, Griffith K, Moon TE (2001) Trends in the incidence of nonmelanoma skin cancers in southeastern Arizona, 1985–1996. J Am Acad Dermatol 45:528–536CrossRefPubMed

Stang A, Stegmaier C, Jockel KH (2003) Nonmelanoma skin cancer in the Federal State of Saarland, Germany, 1995–1999. Br J Cancer 89:1205–1208CrossRefPubMed

Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8–18CrossRefPubMed

Ramos J, Villa J, Ruiz A, Armstrong R, Matta J (2004) UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev 13:2006–2011PubMed

National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Basal and Squamous Cell Skin Cancers version 1.2008. National Comphrensive Cancer Network, Inc.

Saldanha G, Fletcher A, Slater DN (2003) Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatol 148:195–202CrossRefPubMed

Raasch BA, Buettner PG, Garbe C (2006) Basal cell carcinoma: histological classification and body-site distribution. Br J Dermatol 155:401–407CrossRefPubMed

Takenouchi T, Nomoto S, Ito M (2001) Factors influencing the linear depth of invasion of primary basal cell carcinoma. Dermatol Surg 27:393–396CrossRefPubMed

10.

Sherry KR, Reid LA, Wilmshurst AD (2009) A five year review of basal cell carcinoma excisions. J Plast Reconstr Aesth Surg (epub ahead of print)

11.

Walker P, Hill D (2006) Surgical treatment of basal cell carcinomas using standard postoperative histological assessment. Australas J Dermatol 47:1–12CrossRefPubMed

12.

Nagore E, Grau C, Molinero J, Fortea JM (2003) Positive margins in basal cell carcinoma:relationship to clinical features and recurrence risk. A retrospective study of 248 patients. J Eur Acad Dermatol Venereol 17:167–170CrossRefPubMed

13.

Manstein ME, Manstein CH, Smith R (2003) How accurate is frozen section for skin cancers? Ann Plast Surg 50:607–609CrossRefPubMed

14.

Bogdanov-Berezovsky A, Rosenberg L, Cagniano E, Silberstein E (2008) The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas. Isr Med Assoc J 10:344–345PubMed

15.

McLoone NM, Tolland J, Walsh M, Dolan OM (2006) Follow-up of basal cell carcinoma: an audit of current practice. J Eur Acad Dermatol Venereol 20:698–701CrossRef

16.

Park AJ, Strick M, Watson JD (1994) Basal cell carcinomas: do they need to be followed up? J R Coll Surg Edinb 39:109–111PubMed

17.

Hauben DJ, Zirkin H, Mahler D, Sacks M (1982) The biologic behavior of basal cell carcinoma: analysis of recurrence in excised basal cell carcinoma, part II. Plast Reconstr Surg 69:110–116CrossRefPubMed

18.

De Silva SP, Dellon AL (1985) Recurrence rates of positive margin basal cell carcinoma: results of a five year prospective study. J Surg Oncol 28:72–74CrossRefPubMed

19.

Bhatti AZ, Asif S, Alwan M (2006) Factors affecting incomplete excision of nonmelanoma skin cancers in New Zealand. Ann Plast Surg 57:513–516CrossRefPubMed

20.

Wettstein R (2008) Incomplete excision of basal cell carcinoma in the subunits of the nose. Scand J Plast Reconstr Surg Hand Surg 42:92–95CrossRefPubMed

21.

Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R (2005) Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia II. Perineural invasion. J Am Acad Dermatol 53:261–266CrossRefPubMed

22.

Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R (2005) Basal cell carcinoma treated with Mohs surgery in Australia III. Perineural invasion. J Am Acad Dermatol 53:458–463CrossRefPubMed

23.

Robinson JK, Fisher SG (2000) Recurrent basal cell carcinoma after incomplete resection. Arch Dermatol 136:1318–1324CrossRefPubMed

24.

Su SY, Giorlando F, Ek EW, Dieu T (2007) Incomplete excision of basal cell carcinoma: a prospective trial. Plast Reconstr Surg 120:1240–1248CrossRefPubMed

25.

Tan PY, Ek E, Su S, Giorlando F, Dieu T (2007) Incomplete excision of squamous cell carcinoma of the skin: a prospective observational study. Plast Reconstr Surg 120:910–916CrossRefPubMed

26.

Farhi D, Dupin N, Palangie A, Carlotti A, Avril MF (2007) Incomplete excision of basal cell carcinoma: associated factors among 362 consecutive cases. Dermatol Surg 33:1207–1214CrossRefPubMed

Title: Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose
Authors: Görkem Eskiizmir
Gülsüm Gençoğlan
Peyker Temiz
Zafer Hirçin
Aylin Ermertcan
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2011
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1324-x

At a glance: The STEP trials

Springer Medicine

Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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