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01-12-2020 | Stable Angina Pectoris | Study protocol

Acupuncture for chronic stable angina pectoris based on the theory of Meridian-Viscera Association: study protocol for a multicenter randomized controlled trial

Authors: Zhaoxuan He, Yi Yang, Qiao Wen, Tao Yin, Zhengjie Li, Peihong Ma, Hui Zheng, Yunhong Yang, Yongliang Jiang, Jianqiao Fang, Lei Lan, Fang Zeng

Published in: Trials | Issue 1/2020

Abstract

Background

Acupuncture has long been used to treat chronic stable angina pectoris (CSAP), but the acupuncture prescription for CSAP varies. This trial will compare the therapeutic effects between the acupoints on the Heart Meridian and the acupoints on the Lung Meridian for treating CSAP, so as to provide a better prescription for acupuncture treatment of CSAP.

Methods

This is a multicenter randomized controlled trial. A total of 148 CSAP patients will be randomly allocated into two groups through central randomization in a 1:1 ratio. This trial will include a 2-week screening period, a 4-week treatment period, and a 4-week follow-up period. The primary outcome is the frequency of angina attacks from baseline to 4 weeks after inclusion. Secondary outcomes include the frequency of angina attacks from baseline to 4 weeks after acupuncture treatment, the pain intensity of angina, total ischemia burden, heart rate variability, QT dispersion, the score of Seattle Angina Questionnaire, and the score of Short-Form of McGill Pain Questionnaire. These outcome measures will be evaluated at baseline, at the end of acupuncture treatment, and at the end of follow-up.

Discussion

We hypothesize that the effectiveness of puncturing at acupoints on the Heart Meridian will not be the same as those on the Lung Meridian. The results will provide further evidence of Meridian-Viscera Association theory and references for acupoints selection in the clinical practice.

Trial registration

Chinese Clinical Trial Registry ChiCTR1900025804. Registered on September 9, 2019

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Title: Acupuncture for chronic stable angina pectoris based on the theory of Meridian-Viscera Association: study protocol for a multicenter randomized controlled trial
Authors: Zhaoxuan He
Yi Yang
Qiao Wen
Tao Yin
Zhengjie Li
Peihong Ma
Hui Zheng
Yunhong Yang
Yongliang Jiang
Jianqiao Fang
Lei Lan
Fang Zeng
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Stable Angina Pectoris
Acupuncture
Published in: Trials / Issue 1/2020
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-020-04836-8

At a glance: The STEP trials

Springer Medicine

Acupuncture for chronic stable angina pectoris based on the theory of Meridian-Viscera Association: study protocol for a multicenter randomized controlled trial

Abstract

Background

Methods

Discussion

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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