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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 9/2014

Open Access 01-09-2014 | Original article

Stability of spinal bone metastases in breast cancer after radiotherapy

A retrospective analysis of 157 cases

Authors: Ingmar Schlampp, MD, Stefan Rieken, MD, Daniel Habermehl, MD, Thomas Bruckner, MD, Robert Förster, MD, Jürgen Debus, MD PhD, Harald Rief, MD BSc

Published in: Strahlentherapie und Onkologie | Issue 9/2014

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Abstract

Purpose

This retrospective analysis was performed to evaluate osteolytic bone lesions of breast cancer in the thoracic and lumbar spine after radiotherapy (RT) in terms of stability using a validated scoring system.

Methods

The stability of 157 osteolytic metastases, treated from January 2000 to January 2012, in 115 patients with breast cancer was evaluated retrospectively using the Taneichi score. Predictive factors for stability were analyzed and survival rates were calculated.

Results

Eighty-five (54 %) lesions were classified as unstable prior to RT. After 3 and 6 months, 109 (70 %) and 124 (79 %) lesions, respectively, were classified as stable. Thirty fractures were detected prior to RT, and after RT seven cases (4.5 %) with pathologic fractures were found within 6 months. None of the examined predictive factors showed significant correlation with stability 6 months after RT. After a median follow-up of 16.7 months, Kaplan–Meier estimates revealed an overall survival of 83 % after 5 years.

Conclusion

The majority of patients showed an improved or unchanged stability of the involved vertebral bodies after 6 months. The patients showed only minor cancer-related morbidity during follow-up and reached comparably high survival rates.
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Metadata
Title
Stability of spinal bone metastases in breast cancer after radiotherapy
A retrospective analysis of 157 cases
Authors
Ingmar Schlampp, MD
Stefan Rieken, MD
Daniel Habermehl, MD
Thomas Bruckner, MD
Robert Förster, MD
Jürgen Debus, MD PhD
Harald Rief, MD BSc
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 9/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-014-0651-z

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