Issue 6/2011
Content (31 Articles)
Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies
Simendra Singh, Alok K. Gupta
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
Paula M. Fracasso, Kerry J. Williams, Ronald C. Chen, Joel Picus, Cynthia X. Ma, Matthew J. Ellis, Benjamin R. Tan, Timothy J. Pluard, Douglas R. Adkins, Michael J. Naughton, Janet S. Rader, Matthew A. Arquette, James W. Fleshman, Allison N. Creekmore, Sherry A. Goodner, Lisa P. Wright, Zhanfang Guo, Christine E. Ryan, Yu Tao, Eliane M. Soares, Shi-rong Cai, Li Lin, Janet Dancey, Michelle A. Rudek, Howard L. McLeod, Helen Piwnica-Worms
A multicenter phase I trial of metronomic oral vinorelbine plus cisplatin in patients with NSCLC
Athanasios G. Pallis, Vassilis Chandrinos, Georgia Pavlakou, Nikolaos Xenidis, Ioannis Varthalitis, Nikolaos Vardakis, Lambros Vamvakas, Emmanouel Kontopodis, Maria Rovithi, Vassilis Georgoulias
A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)
Petr Sova, Adolf Mistr, Ales Kroutil, Martin Semerád, Hana Chlubnová, Veronika Hrusková, Jirina Chládková, Jaroslav Chládek
Phase II study of docetaxel, capecitabine, and cisplatin as neoadjuvant chemotherapy for locally advanced breast cancer
Yen-Shen Lu, Dar-Ren Chen, Ling-Min Tseng, Dah-Cherng Yeh, Shou-Tung Chen, Chia-Ming Hsieh, Hwei-Chung Wang, Hsien-Tang Yeh, Sung-Hsin Kuo, Chiun-Sheng Huang
A phase II study of paclitaxel by weekly 1-h infusion for advanced or recurrent esophageal cancer in patients who had previously received platinum-based chemotherapy
Ken Kato, Makoto Tahara, Shuichi Hironaka, Kei Muro, Hiroya Takiuchi, Yasuo Hamamoto, Haruhiko Imamoto, Norihito Amano, Taku Seriu
Pharmacokinetic and pharmacodynamic properties of an oral formulation of the histone deacetylase inhibitor Belinostat (PXD101)
N. L. Steele, J. A. Plumb, L. Vidal, J. Tjørnelund, P. Knoblauch, P. Buhl-Jensen, R. Molife, R. Brown, J. S. de Bono, T. R. J. Evans
A phase II and pharmacokinetic study of first line S-1 for advanced gastric cancer in Taiwan
Jen-Shi Chen, Yee Chao, Ruey-Kuen Hsieh, Ann-Lii Cheng, Po-Min Chen, Tzeon-Jye Chiou, Tsu-Yi Chao, Kun-Huei Yeh, Li-Tzong Chen, Jacqueline Whang-Peng
Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model
Meredith K. Chuk, Diane E. Cole, Cynthia McCully, Natalia A. Loktionova, Anthony E. Pegg, Robert J. Parker, Gary Pauly, Brigitte C. Widemann, Frank M. Balis, Elizabeth Fox
Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance
Murugan Kalimutho, Antonella Minutolo, Sandro Grelli, Amanda Formosa, Giulia Sancesario, Alessandra Valentini, Giorgio Federici, Sergio Bernardini
Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant
S. Aubrey Stoch, Cynthia Gargano, Jack Valentine, Matthew P. Braun, M. Gail Murphy, Margaret Fedgchin, Anup Majumdar, Edward Pequignot, Keith M. Gottesdiener, Kevin J. Petty, Deborah Panebianco, Dennis Dean, Walter K. Kraft, Howard E. Greenberg
Phase II study of biweekly S-1 and oxaliplatin combination chemotherapy in metastatic colorectal cancer and pharmacogenetic analysis
Junshik Hong, Sae-Won Han, Hye Seon Ham, Tae-Yong Kim, In Sil Choi, Byung-Su Kim, Do-Youn Oh, Seock-Ah Im, Gyeong Hoon Kang, Yung-Jue Bang, Tae-You Kim
Detection of doxorubicin hydrochloride accumulation in the rat brain after morphine treatment by mass spectrometry
Iacopo Sardi, Giancarlo la Marca, Maria Grazia Giovannini, Sabrina Malvagia, Renzo Guerrini, Lorenzo Genitori, Maura Massimino, Maurizio Aricò
Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator
Linda Rausch, Carol Green, Karen Steinmetz, Sue LeValley, Paul Catz, Nurulain Zaveri, Karen Schweikart, Joseph Tomaszewski, Jon Mirsalis
NCT01110291: induction of CYP3A activity and lowered exposure to docetaxel in patients with primary breast cancer
Johanna Hilli, Liisa Sailas, Sirkku Jyrkkiö, Seppo Pyrhönen, Kari Laine
Phase II study of biweekly docetaxel and S-1 combination chemotherapy as first-line treatment for advanced gastric cancer
Chikara Kunisaki, Masazumi Takahashi, Hirochika Makino, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Jun Kimura, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Kunio Kameda, Fumihiko Kito, Satoshi Morita, Itaru Endo
p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma
Changxia Shao, Chuanwen Lu, Lixia Chen, Patrick P. Koty, Everardo Cobos, Weimin Gao
Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation
Heiko Bugger, Cinthia Guzman, Christoph Zechner, Monica Palmeri, Kerry S. Russell, Raymond R. Russell III
Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin
Chi-Hui Tang, Christi Parham, Ellyn Shocron, Gerald McMahon, Neela Patel
Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor
Edi Levi, Liyue Zhang, Amro Aboukameel, Sunny Rishi, Ramzi M. Mohammad, Lisa Polin, James S. Hatfield, Arun K. Rishi
Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human solid tumor models
Idoia Gamez, Robert P. Ryan, Lakesha D. Reid, Sheri M. Routt, Beth A. Hollister
Feasibility study of adjuvant chemotherapy with S-1 plus cisplatin for gastric cancer
D. Takahari, T. Hamaguchi, K. Yoshimura, H. Katai, S. Ito, N. Fuse, T. Kinoshita, H. Yasui, M. Terashima, M. Goto, N. Tanigawa, K. Shirao, T. Sano, M. Sasako
A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer
Masashi Kanai, Kenichi Yoshimura, Takehiko Tsumura, Masanori Asada, Chihiro Suzuki, Miyuki Niimi, Shigemi Matsumoto, Takafumi Nishimura, Takashi Nitta, Kentaro Yasuchika, Kojiro Taura, Yukiko Mori, Akihiko Hamada, Naoya Inoue, Shinsuke Tada, Kazuhiro Yanagihara, Shujiro Yazumi, Yukio Osaki, Tsutomu Chiba, Iwao Ikai, Masanori Fukushima, Shinji Uemoto, Etsuro Hatano
Phase I/II study of a combination of docetaxel, capecitabine, and cisplatin (DXP) as first-line chemotherapy in patients with advanced gastric cancer
Yoon-Koo Kang, Min-Hee Ryu, Changhoon Yoo, Heung-Moon Chang, Jeong Hwan Yook, Sung Tae Oh, Byung Sik Kim, Tae Won Kim
Interleukin-1 receptor antagonist attenuates cyclophosphamide-induced mucositis in a murine model
Di Xiang, Yiping Guo, Jing Zhang, Jin Gao, Huili Lu, Shunying Zhu, Mingyuan Wu, Yan Yu, Wei Han
Phase II trial of cisplatin plus prednisone in docetaxel-refractory castration-resistant prostate cancer patients
Carlo Buonerba, Piera Federico, Carmine D’Aniello, Pasquale Rescigno, Carla Cavaliere, Livio Puglia, Matteo Ferro, Vincenzo Altieri, Sisto Perdonà, Sabino De Placido, Giuseppe Di Lorenzo
Erratum to: Phase II trial of cisplatin plus prednisone in docetaxel-refractory castration-resistant prostate cancer patients
Carlo Buonerba, Piera Federico, Carmine D’Aniello, Pasquale Rescigno, Carla Cavaliere, Livio Puglia, Matteo Ferro, Vincenzo Altieri, Sisto Perdonà, Sabino De Placido, Giuseppe Di Lorenzo
Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy
Takeshi Masuda, Noboru Hattori, Akinobu Hamada, Hiroshi Iwamoto, Shinichiro Ohshimo, Masashi Kanehara, Nobuhisa Ishikawa, Kazunori Fujitaka, Yoshinori Haruta, Hiroshi Murai, Nobuoki Kohno
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients
Sin-Chi Chew, Onkar Singh, Xiangai Chen, Rathi Devi Ramasamy, Tejal Kulkarni, Edmund J. D. Lee, Eng-Huat Tan, Wan-Teck Lim, Balram Chowbay
Estimating the correct way of calculating the carboplatin dose
Jesús F. Sierra-Sánchez, Triana González-Carrascosa
Prospectives and limitations by a novel algorithm
Karin Holweger, Hans-Peter Lipp