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Cancer Chemotherapy and Pharmacology

Issue 6/2005

Content (12 Articles)

Original Article

A phase IB study of the pharmacokinetics of gemcitabine and pemetrexed, when administered in rapid sequence to patients with advanced solid tumors

Grace K. Dy, Ajit Suri, Joel M. Reid, Jeff A. Sloan, Henry C. Pitot, Steven R. Alberts, Richard M. Goldberg, Pamela J. Atherton, Lorelei J. Hanson, Patrick A. Burch, Joseph Rubin, Charles Erlichman, Alex A. Adjei

Original Article

Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells

Chi-Chih Cheng, Shu-Mei Yang, Chi-Ying Huang, Jung-Chou Chen, Wei-Mao Chang, Shih-Lan Hsu

Original Article

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Omar N. Al Safarjalani, Xiao-Jian Zhou, Reem H. Rais, Junxing Shi, Raymond F. Schinazi, Fardos N. M. Naguib, Mahmoud H. el Kouni

Original Article

Sequence effect of docetaxel and carboplatin on toxicity, tumor response and pharmacokinetics in non-small-cell lung cancer patients: a phase I study of two sequences

Maki Ando, Hideo Saka, Yuichi Ando, Hironobu Minami, Takafumi Kuzuya, Masashi Yamamoto, Atsushi Watanabe, Shuzo Sakai, Kaoru Shimokata, Yoshinori Hasegawa

Original Article

A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer

Henry Q. Xiong, William Plunkett, Robert Wolff, Min Du, Renato Lenzi, James L. Abbruzzese

Original Article

Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies

Debora G. Rodrigues, Durvanei A. Maria, Denise C. Fernandes, Claudete J. Valduga, Ricardo D. Couto, Olga C. M. Ibañez, Raul C. Maranhão

Original Article

Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175

R. L. Hayward, Q. C. Schornagel, R. Tente, J. S. Macpherson, R. E. Aird, S. Guichard, A. Habtemariam, P. Sadler, D. I. Jodrell

Original Article

Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells

Osamu Kishida, Yoshiji Miyazaki, Yoko Murayama, Miyuki Ogasa, Tamana Miyazaki, Takahiro Yamamoto, Kenji Watabe, Shusaku Tsutsui, Tatsuya Kiyohara, Iichiro Shimomura, Yasuhisa Shinomura

Original Article

In vitro schedule-dependent interaction between paclitaxel and oxaliplatin in human cancer cell lines

Risa Tanaka, Hiroshi Ariyama, Baoli Qin, Yasushi Takii, Eishi Baba, Kenji Mitsugi, Mine Harada, Shuji Nakano

Original Article

Additive apoptotic effect of STI571 with the cytoprotective agent amifostine in K-562 cell line

Luciano Vellón, Marcela González-Cid, Marcelo de Campos Nebel, Irene Larripa

Clinical Trial Report

Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients

Peter Nygren, Kenneth Hande, Kevin J. Petty, Margaret Fedgchin, Kristien van Dyck, Anup Majumdar, Debbie Panebianco, Marina de Smet, Tuli Ahmed, M. Gail Murphy, Keith M. Gottesdiener, Veronique Cocquyt, Simon van Belle

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine