Issue 4/2000
Content (12 Articles)
A pharmacodynamic analysis method to determine the relative importance of drug concentration and treatment time on effect
Nancy J. Millenbaugh, M. Guillaume Wientjes, Jessie L.-S. Au
Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles
Pek Yee Lum, Leock Y. Ngo, Aimee H. Bakken, Jashvant D. Unadkat
Phase I/II study of cisplatin, ifosfamide and irinotecan with rhG-CSF support in patients with stage IIIB and IV non-small-cell lung cancer
Akihisa Fujita, Hirotsugu Takabatake, Shigeru Tagaki, Kyuhichiro Sekine
Pharmacokinetics of carboplatin administered in combination with the bradykinin agonist Cereport (RMP-7) for the treatment of brain tumours
Huw D. Thomas, Michael J. Lind, Judith Ford, Norman Bleehen, A. Hilary Calvert, Alan V. Boddy
Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients
Johannes Schüller, Jim Cassidy, Etienne Dumont, Brigitte Roos, Sarah Durston, Ludger Banken, Masahiro Utoh, Kazushige Mori, Erhard Weidekamm, Bruno Reigner
N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE), a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs
Lorne J. Brandes, Gary M. Queen, Frank S. LaBella
Ara-C affects formation of cancer cell DNA synthesome replication intermediates
Waleed Abdel-Aziz, Hai-Yan Jiang, Robert J. Hickey, Linda H. Malkas
Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein (MDR1 gene) mediated drug resistance
Bert L. Lum, Sonja Kaubisch, George A. Fisher, Byron W. Brown, Branimir I. Sikic
Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome
Hai Yan Jiang, Robert J. Hickey, Waleed Abdel-Aziz, Linda H. Malkas
Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide
James L. Flowers, Susan M. Ludeman, Michael P. Gamcsik, O. Michael Colvin, Kai-Liu Shao, Jila H. Boal, James B. Springer, David J. Adams
Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts
Henry S. Friedman, Robert C. Castellino, Gertrude B. Elion, Stephen T. Keir, Peter J. Houghton, Stewart P. Johnson, Darell D. Bigner
Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats
Eugene H. Herman, Jun Zhang, Douglas P. Chadwick, Victor J. Ferrans