Issue 1/2014
Content (21 Articles)
Anti-EGFR MoAb treatment in colorectal cancer: limitations, controversies, and contradictories
Lei Cheng, Wei Ren, Li Xie, Ming Li, Jiang Liu, Jing Hu, Bao-Rui Liu, Xiao-Ping Qian
A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors
Hiroshi Wakui, Noboru Yamamoto, Satoru Kitazono, Hidenori Mizugaki, Shinji Nakamichi, Yutaka Fujiwara, Hiroshi Nokihara, Yasuhide Yamada, Kohei Suzuki, Hironori Kanda, Shiro Akinaga, Tomohide Tamura
Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent
Ying Yi Chen, Pradeep B. Lukka, Wayne R. Joseph, Graeme J. Finlay, James W. Paxton, Mark J. McKeage, Bruce C. Baguley
A phase 1 study of linifanib in combination with carboplatin/paclitaxel as first-line treatment of Japanese patients with advanced or metastatic non-small cell lung cancer (NSCLC)
Hidehito Horinouchi, Noboru Yamamoto, Hiroshi Nokihara, Takeshi Horai, Makoto Nishio, Fumiyoshi Ohyanagi, Atsushi Horiike, Kazuhiko Nakagawa, Masaaki Terashima, Takafumi Okabe, Hiroyasu Kaneda, Mark D. McKee, Dawn M. Carlson, Hao Xiong, Tomohide Tamura
Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans
Eleftheria Tsakalozou, Eyob D. Adane, Yali Liang, Susanne M. Arnold, Markos Leggas
Results of a phase 1, randomized study evaluating the effects of food and diurnal variation on the pharmacokinetics of linifanib
Hao Xiong, Yi-Lin Chiu, Justin L. Ricker, Patricia LoRusso
Absorption, distribution, metabolism, and excretion (ADME) of 14C-sonidegib (LDE225) in healthy volunteers
Markus Zollinger, Frédéric Lozac’h, Eunju Hurh, Corinne Emotte, Hounayda Bauly, Piet Swart
Phase II study evaluating the efficacy, safety, and pharmacodynamic correlative study of dual antiangiogenic inhibition using bevacizumab in combination with sorafenib in patients with advanced malignant melanoma
Devalingam Mahalingam, Laeeq Malik, Muralidhar Beeram, Jordi Rodon, Kamalesh Sankhala, Alain Mita, Daniel Benjamin, Norma Ketchum, Joel Michalek, Anthony Tolcher, John Wright, John Sarantopoulos
Population pharmacokinetics of imatinib in Iranian patients with chronic-phase chronic myeloid leukemia
Ali-Akbar Golabchifar, Saeed Rezaee, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Nahid Mobarghei Dinan, Mohammad-Reza Rouini
Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor Fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
Yi Gu, Jian Wang, Ke Li, Li Zhang, Hongcan Ren, Lixia Guo, Yang Sai, Weihan Zhang, Weiguo Su
A phase I trial of everolimus in combination with 5-FU/LV, mFOLFOX6 and mFOLFOX6 plus panitumumab in patients with refractory solid tumors
Autumn J. McRee, Janine M. Davies, Hanna G. Sanoff, Richard M. Goldberg, Stephen Bernard, E. Claire Dees, Kimberly Keller, Anastasia Ivanova, Bert H. O’Neil
Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
Johanna C. Bendell, David S. Hong, Howard A. Burris III, Aung Naing, Suzanne F. Jones, Gerald Falchook, Patricia Bricmont, Agnes Elekes, Edwin P. Rock, Razelle Kurzrock
A phase I and pharmacokinetic study of capecitabine in combination with radiotherapy in patients with localised inoperable pancreatic cancer
Patricia Roxburgh, Graeme R. Lumsden, James Paul, Sharon Harden, Lorna Sweeting, Allan James, Adrian Crellin, Rosemary Morrison, T. R. Jeffry Evans, Alexander C. McDonald
Phase II multicentre study of efficacy and feasibility of dose-intensified preoperative weekly cisplatin, epirubicin, and paclitaxel (PET) in resectable gastroesophageal cancer
Marine Jary, Francois Ghiringhelli, Marion Jacquin, Francine Fein, Thierry Nguyen, Denis Cleau, Virginie Nerich, Maryame El Gani, Pierre Mathieu, Séverine Valmary-Degano, Laurent Arnould, Catherine Lassabe, Najib Lamfichekh, Serge Fratté, Sophie Paget-Bailly, Franck Bonnetain, Christophe Borg, Stefano Kim
Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide
Wendi V. Rodrigueza, Michael J. Woolliscroft, Abdul-Shukkur Ebrahim, Robert Forgey, Patrick J. McGovren, Gerold Endert, Andreas Wagner, Danielle Holewa, Amro Aboukameel, Richard D. Gill, Charles L. Bisgaier, Richard A. Messmann, Christopher E. Whitehead, Elzbieta Izbicka, Robert Streeper, Michael C. Wick, Gabriela Stiegler, C. A. Stein, David Monsma, Craig Webb, Mina P. Sooch, Steffen Panzner, Ramzi Mohammad, Neal C. Goodwin, Ayad Al-Katib
Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells
Han Min, Min Xu, Zhi-rong Chen, Jun-dong Zhou, Min Huang, Kai Zheng, Xiao-ping Zou
Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501)
Rathi N. Pillai, Joseph Aisner, Suzanne E. Dahlberg, John S. Rogers, Robert S. DiPaola, Seena Aisner, Suresh S. Ramalingam, Joan H. Schiller
Irinotecan and temozolomide brain distribution: a focus on ABCB1
Lauriane Goldwirt, Kevin Beccaria, Alexandre Carpentier, Robert Farinotti, Christine Fernandez
Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors
Monica Mita, Michael Gordon, Lee Rosen, Nirmal Kapoor, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpal Sahai, Mohammad Azab, Robert Bristow, Anthony W. Tolcher
Phase I dose escalation study of capecitabine and erlotinib concurrent with radiation in locally advanced pancreatic cancer
Yixing Jiang, Heath B. Mackley, Eric T. Kimchi, Junjia Zhu, Niraj Gusani, Jussuf Kaifi, Kevin F. Staveley-O’Carroll, Chandra P. Belani
High liposomal doxorubicin tumour tissue distribution, as determined by radiopharmaceutical labelling with 99mTc-LD, is associated with the response and survival of patients with unresectable pleural mesothelioma treated with a combination of liposomal doxorubicin and cisplatin
Oscar Arrieta, Luis-Alberto Medina, Enrique Estrada-Lobato, Laura-Alejandra Ramírez-Tirado, Víctor-Osvaldo Mendoza-García, Jaime de la Garza-Salazar