Top

Published in:

Open Access 01-12-2012 | Case report

Spontaneous tibiotalar arthrodesis as a complication of acute tibial osteomyelitis due to Panton-Valentine leukocidin-producing Staphylococcus aureus: a case report

Authors: Dimitri Ceroni, Rebecca Anderson de la Llana, Tristan Zand, Léopold Lamah, Denis Dominguez, Geraldo De Coulon, Victor Dubois-Ferrière

Published in: Journal of Medical Case Reports | Issue 1/2012

Abstract

Introduction

Strains of Panton-Valentine leukocidin-producing Staphylococcus aureus producing a new pattern of disease have emerged worldwide. Infection with these bacteria typically presents as a life-threatening infection of soft tissues and bones, and may cause potentially devastating consequences.

Case presentation

We report a case of osteoarticular infection caused by Panton-Valentine leukocidin-producing Staphylococcus aureus. A 12-year-old Caucasian girl presented with acute osteomyelitis of the tibia associated with toxic shock syndrome, which was complicated by an unexpected spontaneous ankle arthrodesis.

Conclusions

Osteoarticular infections due to Panton-Valentine leukocidin-producing Staphylococcus aureus appear to be severe, and are characterized by their tendency to evolve towards serious complications. This case highlights the need for early and aggressive surgical procedures in conjunction with appropriate antimicrobial therapy and regular long-term follow-up.

Available only for authorised users

Panton P, Valentine F: Staphylococcal toxin. Lancet. 1932, 1: 506-508.CrossRef

Genestier AL, Michallet MC, Prevost G, Bellot G, Chalabreysse L, Peyrol S, Thivolet F, Etienne J, Lina G, Vallette FM, Vandenesch F, Genestier L: Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J Clin Invest. 2005, 115: 3117-3127. 10.1172/JCI22684.CrossRefPubMedPubMedCentral

Bocchini CE, Hulten KG, Mason EO, Gonzalez BE, Hammerman WA, Kaplan SL: Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children. Pediatrics. 2006, 117: 433-440. 10.1542/peds.2005-0566.CrossRefPubMed

Sdougkos G, Chini V, Papanastasiou DA, Christodoulou G, Tagaris G, Dimitracopoulos G, Spiliopoulou I: Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children. Clin Microbiol Infect. 2007, 13: 651-654. 10.1111/j.1469-0691.2007.01713.x.CrossRefPubMed

Gillet Y, Issartel B, Vanhems P, Fournet JC, Lina G, Bes M, Vandenesch F, Piémont Y, Brousse N, Floret D, Etienne J: Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002, 359: 753-759. 10.1016/S0140-6736(02)07877-7.CrossRefPubMed

Holmes A, Ganner M, McGuane S, Pitt TL, Cookson BD, Kearns AM: Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol. 2005, 43: 2384-2390. 10.1128/JCM.43.5.2384-2390.2005.CrossRefPubMedPubMedCentral

Lina G, Piemont Y, Godail-Gamot F, Bes M, Peter MO, Gauduchon V, Vandenesch F, Etienne J: Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999, 29: 1128-1132. 10.1086/313461.CrossRefPubMed

Moumile K, Cadilhac C, Lina G, Berche P, Glorion C, Ferroni A: Severe osteoarticular infection associated with Panton-Valentine leukocidin-producing Staphylococcus aureus. Diagn Microbiol Infect Dis. 2006, 56: 95-97. 10.1016/j.diagmicrobio.2006.03.007.CrossRefPubMed

Mitchell PD, Hunt DM, Lyall H, Nolan M, Tudor-Williams G: Panton-Valentine leukocidin-secreting Staphylococcus aureus causing severe musculoskeletal sepsis in children. A new threat. J Bone Joint Surg Br. 2007, 89: 1239-1242. 10.1302/0301-620X.89B9.19485.CrossRefPubMed

10.

Salliot C, Zeller V, Puechal X, Manceron V, Sire S, Varache N, Etienne J, Desplaces N, Ziza JM: Panton-Valentine leukocidin-producing Staphylococcus aureus infections: report of 4 French cases. Scand J Infect Dis. 2006, 38: 192-195. 10.1080/00365540500388776.CrossRefPubMed

11.

Dohin B, Gillet Y, Kohler R, Lina G, Vandenesch F, Vanhems P, Floret D, Etienne J: Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus. Pediatr Infect Dis J. 2007, 26: 1042-1048. 10.1097/INF.0b013e318133a85e.CrossRefPubMed

12.

Ellington MJ, Hope R, Ganner M, Ganner M, East C, Brick G, Kearns AM: Is Panton-Valentine leucocidin associated with the pathogenesis of Staphylococcus aureus bacteraemia in the UK?. J Antimicrob Chemother. 2007, 60: 402-405. 10.1093/jac/dkm206.CrossRefPubMed

13.

van Duijkeren E, Wolfhagen MJ, Heck ME, Wannet WJ: Transmission of a Panton-Valentine leucocidin-positive, methicillin-resistant Staphylococcus aureus strain between humans and a dog. J Clin Microbiol. 2005, 43: 6209-6211. 10.1128/JCM.43.12.6209-6211.2005.CrossRefPubMedPubMedCentral

14.

Witte W, Strommenger B, Cuny C, Heuck D, Nuebel U: Methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leucocidin gene in Germany in 2005 and 2006. J Antimicrob Chemother. 2007, 60: 1258-1263. 10.1093/jac/dkm384.CrossRefPubMed

15.

Martinez-Aguilar G, Avalos-Mishaan A, Hulten K, Hammerman W, Mason EO, Kaplan SL: Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J. 2004, 23: 701-706. 10.1097/01.inf.0000133044.79130.2a.CrossRefPubMed

16.

Shirtliff ME, Mader JT: Acute septic arthritis. Clin Microbiol Rev. 2002, 15: 527-544. 10.1128/CMR.15.4.527-544.2002.CrossRefPubMedPubMedCentral

17.

Roy S, Bhawan J: Ultrastructure of articular cartilage in pyogenic arthritis. Arch Pathol. 1975, 99: 44-47.PubMed

18.

Riegels-Nielsen P, Frimodt-Moller N, Sorensen M, Jensen JS: Antibiotic treatment insufficient for established septic arthritis. Staphylococcus aureus experiments in rabbits. Acta Orthop Scand. 1989, 60: 113-115. 10.3109/17453678909150107.CrossRefPubMed

19.

Smith RL, Schurman DJ: Bacterial arthritis. A staphylococcal proteoglycan-releasing factor. Arthritis Rheum. 1986, 29: 1378-1386. 10.1002/art.1780291111.CrossRefPubMed

20.

Smith RL, Schurman DJ, Kajiyama G, Mell M, Gilkerson E: The effect of antibiotics on the destruction of cartilage in experimental infectious arthritis. J Bone Joint Surg Am. 1987, 69: 1063-1068.PubMed

Title: Spontaneous tibiotalar arthrodesis as a complication of acute tibial osteomyelitis due to Panton-Valentine leukocidin-producing Staphylococcus aureus: a case report
Authors: Dimitri Ceroni
Rebecca Anderson de la Llana
Tristan Zand
Léopold Lamah
Denis Dominguez
Geraldo De Coulon
Victor Dubois-Ferrière
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-6-202

At a glance: The STEP trials

Springer Medicine

Spontaneous tibiotalar arthrodesis as a complication of acute tibial osteomyelitis due to Panton-Valentine leukocidin-producing Staphylococcus aureus: a case report

Abstract

Introduction

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

Thrombocytopenia and absent radii (TAR) syndrome associated with bilateral congenital cataract: a case report

Minimal access direct spondylolysis repair using a pedicle screw-rod system: a case series

Metoprolol-induced visual hallucinations: a case series

Successful toric intraocular lens implantation in a patient with induced cataract and astigmatism after posterior chamber toric phakic intraocular lens implantation: a case report

Cauda equina syndrome as the initial presenting clinical feature of medulloblastoma: a case report

Giant primary adrenal hydatid cyst presenting with arterial hypertension: a case report and review of the literature