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Supportive Care in Cancer
Published in: Supportive Care in Cancer 7/2021

01-07-2021 | Spirometry | Original Article

Functional capacity, pulmonary function, and quality of life in hematopoietic stem cell transplantation survivors

Authors: Giana Berleze Penna, Tassiana Costa da Silva, Alessandra Aparecida Paz, Bruna Ziegler

Published in: Supportive Care in Cancer | Issue 7/2021

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Abstract

Objective

Hematopoietic stem cell transplantation (HSCT) is used as a treatment for several diseases. The objective was to evaluate the functional capacity, pulmonary function, and quality of life (QoL) in HSCT survivors.

Methods

The patients were submitted to spirometry and six-minute walk test (6MWT) and evaluation of QoL (Functional Assessment of Cancer Therapy Bone Marrow Transplantation—FACT-BMT) and the level of physical activity (Human Activity Profile—HAP) in the post-HSCT outpatient ambulatory.

Results

The sample was composed of 103 individuals with a mean age of 42.1 ± 12 and a median HSCT time of 5 (2–11) years. The average distance walked in the 6MWT was 524.7 ± 73.5 m; the FACT-BMT score, 82 ± 8.7 points; FEV1, 76.8 ± 22.6%; and HAP, 71.9 ± 11.2 points. There was a significant difference between debilitated and physically active individuals for the variables: forced expiratory volume in the first second (FEV1) in liters (p = 0.008) and % of predicted (p = 0.017), FEV1/FVC (p = 0.032), distance on the 6MWT (p < 0.001), fatigue after the 6MWT (p < 0.001), and physical well-being (p = 0.005).

Conclusions

HSCT survivors have long-term changes in functional capacity, pulmonary function, and QoL. Subjects more active had better results in pulmonary function and functional capacity.
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Metadata
Title
Functional capacity, pulmonary function, and quality of life in hematopoietic stem cell transplantation survivors
Authors
Giana Berleze Penna
Tassiana Costa da Silva
Alessandra Aparecida Paz
Bruna Ziegler
Publication date
01-07-2021
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 7/2021
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-020-05947-3

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