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Current Neurology and Neuroscience Reports

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25-01-2024 | Spinocerebellar Ataxia | Review

Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias

Authors: Chi-Ying R. Lin, Sheng-Han Kuo, Puneet Opal

Published in: Current Neurology and Neuroscience Reports | Issue 3/2024

Abstract

Purpose of Review

Spinocerebellar ataxias (SCAs) are autosomal dominant degenerative syndromes that present with ataxia and brain stem abnormalities. This review describes the cognitive and behavioral symptoms of SCAs in the context of recent knowledge of the role of the cerebellum in higher intellectual function.

Recent Findings

Recent studies suggest that patients with spinocerebellar ataxia can display cognitive deficits even early in the disease. These have been given the term cerebellar cognitive affective syndrome (CCAS). CCAS can be tracked using newly developed rating scales. In addition, patients with spinocerebellar ataxia also display impulsive and compulsive behavior, depression, anxiety, fatigue, and sleep disturbances.

Summary

This review stresses the importance of recognizing non-motor symptoms in SCAs. There is a pressing need for novel therapeutic interventions to address these symptoms given their deleterious impact on patients’ quality of life.

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Title: Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias
Authors: Chi-Ying R. Lin
Sheng-Han Kuo
Puneet Opal
Publication date: 25-01-2024
Publisher: Springer US
Keywords: Spinocerebellar Ataxia
Mood Disorders
Affective Disorder
Anxiety
Fatigue
Published in: Current Neurology and Neuroscience Reports / Issue 3/2024
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-024-01331-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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