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01-09-2020 | Spinal Stenosis | Original Article

Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study

Authors: Nils H. Ulrich, Isaac Gravestock, Sebastian Winklhofer, Iliya Peyneshki, Maria M. Wertli, Giuseppe Pichierri, Tamás F. Fekete, François Porchet, Mazda Farshad, Johann Steurer, Jakob M. Burgstaller, the LSOS Study Group

Published in: European Spine Journal | Issue 9/2020

Abstract

Purpose

Spinal epidural lipomatosis (SEL) is defined as an abnormal and extensive accumulation of unencapsulated adipose tissue within the spinal epidural space. To date, there is a lack of high-level evidence studies reporting the outcome of surgical treatment of symptomatic SEL in patients with lumbar spinal stenosis (LSS). The aim was to compare clinical outcomes in patients with symptomatic LSS with and without SEL who underwent decompression surgery alone at the 12- and 24-month follow-up.

Methods

One hundred and eighty-three patients met the inclusion criteria, of which 14 had mainly SEL on at least one level operated in addition to possible degenerative changes on other levels and 169 degenerative LSS only. The main outcomes were pain (Spinal Stenosis Measure (SSM) symptoms), disability (SSM function), and quality of life [EQ-5D-3L summary index (SI)] at 24-month follow-up, and minimal clinically important difference (MCID) in SSM symptoms, SSM function, and EQ-5D-3L SI.

Results

The multiple regression linear models showed that SEL was associated with worse SSM symptoms (p = 0.045) and EQ-5D-3L SI scores (p = 0.026) at 24-month follow-up, but not with worse SSM function scores. Further, depression (in all models) was negatively associated with better clinical outcomes at 24-month follow-up. In the outcomes SSM symptoms and EQ-5D-3L SI, distinctly more patients in the classical LSS group reached MCID than in the SEL group (71.3% and 62.3% vs. 50.0% and 42.9%).

Conclusions

Our study demonstrated that decompression alone surgery was associated with significant improvement in disability in both groups at 2 years, but not in pain and quality of life in patients with SEL.

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Title: Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study
Authors: Nils H. Ulrich
Isaac Gravestock
Sebastian Winklhofer
Iliya Peyneshki
Maria M. Wertli
Giuseppe Pichierri
Tamás F. Fekete
François Porchet
Mazda Farshad
Johann Steurer
Jakob M. Burgstaller
the LSOS Study Group
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keyword: Spinal Stenosis
Published in: European Spine Journal / Issue 9/2020
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-020-06449-w

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Springer Medicine

Two-year outcome comparison of decompression in 14 lipomatosis cases with 169 degenerative lumbar spinal stenosis cases: a Swiss prospective multicenter cohort study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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