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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 6/2018

01-06-2018 | Head and Neck Oncology

SPECT/CT: Looking Beyond Sentinel Lymph Node Identification for Improving Patient Outcomes

Authors: Robert Sibley, MD, Rathan M. Subramaniam, MD, PhD, MPH

Published in: Annals of Surgical Oncology | Issue 6/2018

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Excerpt

Sentinel lymph node (SLN) identification is required for accurate prognostication for patients with head and neck melanoma.1 In clinical practice, identifying SLNs can be challenging. This is particularly true for patients with head and neck melanomas, which are associated with higher rates of false negative biopsies.2 Additionally, the drainage pattern of the head and neck is complex. Drainage patterns can be discordant from predicted patterns,3,4 and a single lesion can drain to multiple basins.4‐7 Unfortunately, these challenges have resulted in a relative paucity of research for SLN studies in patients with head and neck melanoma. …
Literature
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Monroe MM, Pattisapu P, Myers JN, Kupferman ME. Sentinel lymph node biopsy provides prognostic value in thick head and neck melanoma. Otolaryngol Head Neck Surg. 2015;153(3):372–78.CrossRefPubMed
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Lee DY, Huynh KT, Teng A, et al. Predictors and survival impact of false-negative sentinel nodes in melanoma. Ann Surg Oncol. 2016;23(3):1012–18.CrossRefPubMed
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Lin D, Franc BL, Kashani-Sabet M, Singer MI. Lymphatic drainage patterns of head and neck cutaneous melanoma observed on lymphoscintigraphy and sentinel lymph node biopsy. Head Neck. 2006;28(3):249–55.CrossRefPubMed
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Kaveh AH, Seminara NM, Barnes MA, et al. Aberrant lymphatic drainage and risk for melanoma recurrence after negative sentinel node biopsy in middle-aged and older men. Head Neck. 2016;38(Suppl 1):E754–60.CrossRefPubMed
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Vidal M, Vidal-Sicart S, Torres F, Ruiz DM, Paredes P, Pons F. Correlation between theoretical anatomical patterns of lymphatic drainage and lymphoscintigraphy findings during sentinel node detection in head and neck melanomas. Eur J Nucl Med Mol Imaging. 2016;43(4):626–34.CrossRefPubMed
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Bostick P, Essner R, Sarantou T, et al. Intraoperative lymphatic mapping for early-stage melanoma of the head and neck. Am J Surg. 1997;174(5):536–39.CrossRefPubMed
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Stewart CL, Gleisner A, Kwak J, et al. Implications of sentinel lymph node drainage to multiple basins in head and neck melanoma. Ann Surg Oncol. 2017;24(5):1386–91.CrossRefPubMed
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Jimenez-Heffernan A, Ellmann A, Sado H, et al. Results of a prospective multicenter international atomic energy agency sentinel node trial on the value of SPECT/CT over planar imaging in various malignancies. J Nucl Med. 2015;56(9):1338–44.CrossRefPubMed
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Stoffels I, Muller M, Geisel MH, et al. Cost-effectiveness of preoperative SPECT/CT combined with lymphoscintigraphy versus lymphoscintigraphy for sentinel lymph node excision in patients with cutaneous malignant melanoma. Eur J Nucl Med Mol Imaging. 2014;41(9):1723–31.CrossRefPubMed
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Trinh BB, CB, Gleisner A, Kwak JJ, Morgan R, McCarter MD, Gajdos C, Kounalakis N. SPECT/CT adds distinct lymph node basins and influences radiologic findings and surgical approach for sentinel lymph node biopsy in head and neck melanoma. Ann Surg Oncol. In press.
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Moody JA, Ali RF, Carbone AC, Singh S, Hardwicke JT. Complications of sentinel lymph node biopsy for melanoma: a systematic review of the literature. Eur J Surg Oncol. 2017;43(2):270–77.CrossRefPubMed
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Moody JA, Botham SJ, Dahill KE, Wallace DL, Hardwicke JT. Complications following completion lymphadenectomy versus therapeutic lymphadenectomy for melanoma: a systematic review of the literature. Eur J Surg Oncol. 2017;43(9):1760–67.CrossRefPubMed
Metadata
Title
SPECT/CT: Looking Beyond Sentinel Lymph Node Identification for Improving Patient Outcomes
Authors
Robert Sibley, MD
Rathan M. Subramaniam, MD, PhD, MPH
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 6/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-6301-9

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