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Archives of Gynecology and Obstetrics

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01-06-2010 | Materno-fetal Medicine

Specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions are not significantly different from healthy controls

Authors: Michael K. Bohlmann, Doerte W. Luedders, Thomas Strowitzki, Michael von Wolff

Published in: Archives of Gynecology and Obstetrics | Issue 6/2010

Abstract

Objective

To analyze concentrations of endometrial leukocytes in patients with idiopathic-repeated abortions.

Materials and methods

Biopsies of exactly dated secretory endometrium in 25 patients with idiopathic-repeated abortions and 10 control patients without a history of miscarriage were compared with respect to the concentrations of T-helper cells (CD4), cytotoxic T-cells (CD8), B-cells (CD19) and uterine natural killer cells (CD56) by immunohistochemistry and RNase protection assays.

Results

All examined cells were detectable within secretory endometrium. No statistically significant differences of the examined immune-cell concentrations were seen between the control group and the repeated miscarriage group by either test.

Conclusion

This study suggests that the concentrations of specific endometrial leukocytes in a non-pregnant cycle are not associated with repeated pregnancy loss. Thus, the hypothesis of an altered endometrial immunity in patients with repeated miscarriages, symbolized by persistently differing local immune-cell concentrations, has to be questioned.

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Title: Specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions are not significantly different from healthy controls
Authors: Michael K. Bohlmann
Doerte W. Luedders
Thomas Strowitzki
Michael von Wolff
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 6/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1179-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions are not significantly different from healthy controls

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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