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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 1/2019

01-02-2019 | Research Article

Spatial Patterns of Hypometabolism and Amyloid Deposition in Variants of Alzheimer’s Disease Corresponding to Brain Networks: a Prospective Cohort Study

Authors: Ying Wang, Zhihong Shi, Nan Zhang, Li Cai, Yansheng Li, Hailei Yang, Shaobo Yao, Xiling Xing, Yong Ji, Shuo Gao

Published in: Molecular Imaging and Biology | Issue 1/2019

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Abstract

Purpose

To identify the most vulnerable network among typical and three variants of Alzheimer’s disease (AD) and to link amyloid-β (Aβ) deposition and downstream network dysfunction.

Procedures

In this study, 38 typical AD, 11 frontal variants, 8 logopenic variants, 6 posterior variants, and 20 normal controls were enrolled. 2-(4′-[11C] Methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) and 2-deoxy-2-[18]fluoro-d-glucose ([18F]FDG) positron emission tomography (PET) imaging were performed. Voxel-wise statistical analysis was used for [18F]FDG analysis, whereas two-sample t test was performed between each AD group and control group. Moreover, the goodness of fit (GOF) of t-maps with brain functional network templates was assessed, and the most vulnerable network in each phenotypic of AD was chosen as volume of interests (VOIs). [11C]PIB binding potential (BPND) of VOIs were generated by using PMOD software. In addition, statistical analysis of BPND among four types of AD in each specific network was calculated by SPSS software.

Results

The hypometabolism patterns indicated that in typical and frontal variants of AD, the most vulnerable network was the left executive control network (GOF score = 4.3, 5.0). For the logopenic variant, the highest GOF score (1.9) belonged to the auditory network. For the posterior variant, the higher visual network was the most vulnerable (GOF score = 6.0). The [11C]PIB BPND showed that there were no significant differences (p > 0.05) among AD groups within the specific networks.

Conclusion

The phenotypic diversity of AD correlates with specific functional network failure; however, Aβ plaques do not associate with specific network vulnerability.
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Metadata
Title
Spatial Patterns of Hypometabolism and Amyloid Deposition in Variants of Alzheimer’s Disease Corresponding to Brain Networks: a Prospective Cohort Study
Authors
Ying Wang
Zhihong Shi
Nan Zhang
Li Cai
Yansheng Li
Hailei Yang
Shaobo Yao
Xiling Xing
Yong Ji
Shuo Gao
Publication date
01-02-2019
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 1/2019
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-018-1219-6

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