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Inflammation Research
Published in: Inflammation Research 10/2014

01-10-2014 | Short Communication

Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study

Authors: Elçin Şehitoğlu, Filiz Çavuş, Canan Ulusoy, Melike Küçükerden, Arda Örçen, Deniz Akbaş-Demir, Arzu Çoban, Burçak Vural, Erdem Tüzün, Recai Türkoğlu

Published in: Inflammation Research | Issue 10/2014

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Abstract

Objective

To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS).

Methods

Sera of 13 RIS patients were screened by a protein macroarray derived from human fetal brain cDNA library.

Results

Sequencing of a clone with the highest signal intensity revealed sorcin as a potential target autoantigen in RIS patients. ELISA studies showed high-titer sorcin-antibodies in 3 of 4 RIS patients who converted to RRMS in a 5-year follow-up period and 13 of 23 control RRMS patients.

Conclusion

The value of sorcin antibody as a predictor of conversion from RIS to RRMS requires to be tested in larger prospective studies.
Literature
1.
Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, Hauser SL, Pelletier D. Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology. 2009;72:800–5.PubMedCrossRef
2.
3.
Krumbholz M, Derfuss T, Hohlfeld R, Meinl E. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol. 2012;8:613–23.PubMedCrossRef
4.
Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol. 2005;58:840–6.PubMedCrossRef
5.
Vural B, Uğurel E, Tüzün E, et al. Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet’s disease. J Neuroimmunol. 2011;239:91–7.PubMedCrossRef
6.
Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med. 2012;367:115–23.PubMedCrossRef
7.
Pickel VM, Clarke CL, Meyers MB. Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: association with ryanodine receptors and intracellular calcium release. J Comp Neurol. 1997;386:625–34.PubMedCrossRef
8.
Cordiglieri C, Odoardi F, Zhang B, et al. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain. 2010;133:1930–43.PubMedCrossRefPubMedCentral
9.
Ruiz A, Matute C, Alberdi E. Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes. Cell Death Dis. 2010;1:e54.PubMedCrossRefPubMedCentral
Metadata
Title
Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study
Authors
Elçin Şehitoğlu
Filiz Çavuş
Canan Ulusoy
Melike Küçükerden
Arda Örçen
Deniz Akbaş-Demir
Arzu Çoban
Burçak Vural
Erdem Tüzün
Recai Türkoğlu
Publication date
01-10-2014
Publisher
Springer Basel
Published in
Inflammation Research / Issue 10/2014
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-014-0754-0

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