Published in:
Open Access
01-02-2019 | Head and Neck
Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis
Authors:
Yun-Fei Zhang, Hong Li, Xue-Mei Wang, Yun-Fei Cai
Published in:
European Radiology
|
Issue 2/2019
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Abstract
Objectives
To assess the performance of sonoelastography for differential diagnosis between malignant and benign parotid lesions using a meta-analysis.
Methods
An independent literature search of English medical databases, such as PubMed, Embase and Medline (
Embase.com), Web of Science, Cochrane Library and Ovid was performed. The diagnostic accuracy of sonoelastography was compared with that of histopathology and/or cytology, which was used as reference standard. The pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the curve (AUC) were calculated to evaluate the accuracy of sonoelastography. A meta-regression analysis evaluating imaging mechanisms, shear wave elastography techniques, assessment methods and QUADAS scores was performed.
Results
Ten eligible studies that included a total sample of 711 patients with 725 parotid lesions were included. Sonoelastography showed a pooled sensitivity of 0.67 (95% CI 0.59–0.74), specificity of 0.64 (95% CI 0.60–0.68), DOR of 8.00 (95% CI 2.96–21.63) and an AUC of 0.77. The results of the meta-regression analysis revealed that no heterogeneity was due to the imaging mechanism (p = 0.119), shear wave elastography technique (p = 0.473) or QUADAS score (p = 0.462). However, the assessment method was a significant factor that affected the study heterogeneity (p = 0.035). According to the subgroup analysis, quantitative and semiquantitative methods performed better than qualitative ones.
Conclusion
Overall, sonoelastography has a limited value for differential diagnosis between malignant and benign parotid lesions. Quantitative and semiquantitative methods perform better than qualitative ones.
Key Points
• Overall, sonoelastography has a limited value for differential diagnosis between malignant and benign parotid lesions.
• Quantitative and semiquantitative assessment methods perform better than qualitative ones.
• Semiquantitative and quantitative methods are automatically calculated by an ultrasound machine and are thus less operator-dependent.