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Published in: Pediatric Nephrology 10/2015

01-10-2015 | Review

Solving the genetic puzzle of systemic lupus erythematosus

Authors: Wanling Yang, Yu Lung Lau

Published in: Pediatric Nephrology | Issue 10/2015

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Abstract

In recent years, genome-wide association studies on systemic lupus erythematosus (SLE) have significantly improved our understanding of the genetic architecture of this prototypic autoimmune disease. However, there is still a long way to go before we can fully understand the genetic factors for this very heterogeneous disease and the interplays between environmental factors and genetic predisposition that lead to the pathogenesis of SLE. Here we summarize the recent advances in our understanding of the genetics of SLE and discuss the future directions towards fully elucidating the mechanisms of this disease.
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Metadata
Title
Solving the genetic puzzle of systemic lupus erythematosus
Authors
Wanling Yang
Yu Lung Lau
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-014-2947-8

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