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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 7/2011

01-07-2011 | Original article

Soluble MUC1 and serum MUC1-specific antibodies are potential prognostic biomarkers for platinum-resistant ovarian cancer

Authors: Raluca A. Budiu, Gina Mantia-Smaldone, Esther Elishaev, Tianjiao Chu, Julia Thaller, Kathryn McCabe, Diana Lenzner, Robert P. Edwards, Anda M. Vlad

Published in: Cancer Immunology, Immunotherapy | Issue 7/2011

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Abstract

MUC1 (CA15-3) and MUC16 (CA125) tumor-associated antigens are upregulated in ovarian cancer and can be detected in patients’ sera by standardized tests. We postulated that increased MUC1 and MUC16 antigens augment antibody responses in platinum-resistant ovarian cancer patients and that the frequency and intensity of these responses can be used as immune biomarkers of treatment response and disease outcome. We measured MUC1 and MUC16 tumor expression by immunohistochemistry (IHC), assessed serum antigenic levels and quantitated circulating antibodies by ELISA in a cohort of 28 ovarian cancer patients with platinum-resistant or platinum-refractory ovarian cancer, and treated with intraperitoneal (IP) interleukin-2 (IL-2). MUC1 and MUC16 were overexpressed in tumor samples and showed differential distribution profiles. Serum MUC1 (CA15-3) measurements were elevated in all patients and significantly correlated with increased risk of death (P = 0.003). MUC1-specific IgM and IgG anitbodies were found in 92 and 50% of cases, respectively. Patients with progressive disease had higher mean anti-MUC1 IgG than responders at both early (P = 0.025) and late (P = 0.022) time points during IP IL-2 treatment. Anti-MUC1 IgM antibodies inversely correlated with overall survival at both early (P = 0.052) and late (P = 0.009) time points. In contrast to MUC1, neither soluble MUC16 nor MUC16-specific antibodies were significantly associated with clinical response or overall survival in this study. Increased serum MUC1 and high anti-MUC1 antibody levels are prognostic for poor clinical response and reduced overall survival in platinum-resistant or platinum-refractory ovarian cancer.
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Metadata
Title
Soluble MUC1 and serum MUC1-specific antibodies are potential prognostic biomarkers for platinum-resistant ovarian cancer
Authors
Raluca A. Budiu
Gina Mantia-Smaldone
Esther Elishaev
Tianjiao Chu
Julia Thaller
Kathryn McCabe
Diana Lenzner
Robert P. Edwards
Anda M. Vlad
Publication date
01-07-2011
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 7/2011
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-011-1010-x

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