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Critical Care
Published in: Critical Care 4/2011

01-08-2011 | Letter

Soluble CD40 ligand is not solely related to the presence and severity of sepsis

Authors: Michelle S Chew, Henrik Thorlacius

Published in: Critical Care | Issue 4/2011

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Excerpt

We read with interest the recently published paper by Lorente and colleagues reporting that levels of soluble CD40 ligand (CD40L) are increased in septic patients compared with healthy controls and that increased circulating CD40L levels may be an independent predictor of mortality in patients with sepsis [1]. The relationship between platelets and soluble CD40L seen in this study is consistent with previous data showing that soluble CD40L is mainly released from activated platelets and mediates neutrophil-induced lung injury in sepsis [2]. …
Literature
1.
Lorente L, Martin MM, Varo N, Borreguero-León JM, Solé-Violán J, Blanquer J, Labarta L, Diaz C, Jiménez A, Pastor E, Belmonte F, Orbe J, Rodriguez JA, Gómez-Melini E, Ferrer-Aguero JM, Ferreres J, Lliminana MC, Páramo JA: Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care. 2011, 15: R97-10.1186/cc10104.PubMedPubMedCentralCrossRef
2.
Rahman M, Zhang S, Chew M, Ersson A, Jeppson B, Thorlacius H: Platelet derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg. 2009, 250: 783-790. 10.1097/SLA.0b013e3181bd95b7.PubMedCrossRef
3.
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA: CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Am J Resp Crit Care Med. 2008, 177: 301-308.PubMedPubMedCentralCrossRef
4.
Chew M, Rahman M, Ihrman L, Ersson A, Zhang S, Thorlacius H: Soluble CD40L (sCD40L) is increased in patients with shock. Inflamm Res. 2010, 59: 979-982. 10.1007/s00011-010-0213-5.PubMedCrossRef
Metadata
Title
Soluble CD40 ligand is not solely related to the presence and severity of sepsis
Authors
Michelle S Chew
Henrik Thorlacius
Publication date
01-08-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10316

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