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Published in: Journal of Maxillofacial and Oral Surgery 4/2022

16-11-2021 | Case Report

Solitary Neurofibroma of Mandible in a 2-Year-Old Child: A Rare Case Report and Review of Literature

Authors: Dibya Falgoon Sarkar, Niranjan Mishra, Debashish Pati, Sandeep Kumar Samal

Published in: Journal of Maxillofacial and Oral Surgery | Issue 4/2022

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Abstract

Solitary intraosseous neurofibromas of mandible are very rare and only 40 cases are documented. This case report presents one of the youngest documented case of solitary neurofibroma of mandible, in a 2-years old male child. The tumour was symptomatic and presented as a swelling over right posterior region of mandible. The patient underwent conservative excision under general anaesthesia. The inferior alveolar nerve was preserved. Histopathology was suggestive of benign nerve sheath tumour. Immunohistochemistry showed moderate S-100 and strong CD34 positivity. Postoperative healing was uneventful. This report also reviews forty previously reported cases of solitary intraosseous neurofibromas of the mandible.
Literature
1.
go back to reference Lassmann H, Jurecka W, Lassmann G, Gebhart W, Matras H, Watzek G (1977) Different types of benign nerve sheath tumors. Light microscopy, electron microscopy and autoradiography. Virchows Arch A Pathol Anat Histol 375:197–210CrossRef Lassmann H, Jurecka W, Lassmann G, Gebhart W, Matras H, Watzek G (1977) Different types of benign nerve sheath tumors. Light microscopy, electron microscopy and autoradiography. Virchows Arch A Pathol Anat Histol 375:197–210CrossRef
2.
go back to reference Papadopoulos H, Zachariades N, Angelopoulos AP (1981) Neurofibroma of the mandible. Review of the literature and report of a case. Int J Oral Surg 10:293–297CrossRef Papadopoulos H, Zachariades N, Angelopoulos AP (1981) Neurofibroma of the mandible. Review of the literature and report of a case. Int J Oral Surg 10:293–297CrossRef
3.
go back to reference Fortier K, Prabhu S, Levin LG, Peters T, Reebye UN (2018) Solitary intraosseous mandibular neurofibroma: clinical case study. J Dent Oral Health 5:1–7 Fortier K, Prabhu S, Levin LG, Peters T, Reebye UN (2018) Solitary intraosseous mandibular neurofibroma: clinical case study. J Dent Oral Health 5:1–7
4.
go back to reference Vivek N, Manikandhan R, James PC, Rajeev R (2006) Solitary intraosseous neurofibroma of mandible. Indian J Dent Res 17:135–138CrossRef Vivek N, Manikandhan R, James PC, Rajeev R (2006) Solitary intraosseous neurofibroma of mandible. Indian J Dent Res 17:135–138CrossRef
5.
go back to reference Apostolidis C, Anterriotis D, Rapidis AD, Angelopoulos AP (2001) Solitary intraosseous neurofibroma of the inferior alveolar nerve: report of a case. J Oral Maxillofac Surg 59(2):232–235CrossRef Apostolidis C, Anterriotis D, Rapidis AD, Angelopoulos AP (2001) Solitary intraosseous neurofibroma of the inferior alveolar nerve: report of a case. J Oral Maxillofac Surg 59(2):232–235CrossRef
6.
go back to reference Behrad S, Sohanian S, Ghanbarzadegan A (2020) Solitary intraosseous neurofibroma of the mandible: report of an extremely rare histopathologic feature. Indian J Pathol Microbiol 63:276–278CrossRef Behrad S, Sohanian S, Ghanbarzadegan A (2020) Solitary intraosseous neurofibroma of the mandible: report of an extremely rare histopathologic feature. Indian J Pathol Microbiol 63:276–278CrossRef
7.
go back to reference Iqbal A, Tamgadge S, Tamgadge A, Chande M (2018) Intraosseous neurofibroma in a 13-year-old male patient: a case report with review of literature. J Cancer Res Ther 14(3):712–715CrossRef Iqbal A, Tamgadge S, Tamgadge A, Chande M (2018) Intraosseous neurofibroma in a 13-year-old male patient: a case report with review of literature. J Cancer Res Ther 14(3):712–715CrossRef
8.
go back to reference Inoue T, Elaskary M, Shima A, Hirai H, Suzuki F, Matsuda M (2017) Trigeminal neurofibroma in the infratemporal fossa arising from the inferior alveolar nerve: a case report. Mol Clin Oncol 7(5):825–829CrossRef Inoue T, Elaskary M, Shima A, Hirai H, Suzuki F, Matsuda M (2017) Trigeminal neurofibroma in the infratemporal fossa arising from the inferior alveolar nerve: a case report. Mol Clin Oncol 7(5):825–829CrossRef
9.
go back to reference Narang BR, Palaskar SJ, Bartake AR, Pawar RB, Rongte S (2017) Intraosseous neurofibroma of the mandible: a case report and review of literature. J Clin Diagn Res 11(2):ZD06–ZD08 Narang BR, Palaskar SJ, Bartake AR, Pawar RB, Rongte S (2017) Intraosseous neurofibroma of the mandible: a case report and review of literature. J Clin Diagn Res 11(2):ZD06–ZD08
11.
go back to reference Saravani S, Kadeh H, Nosratzehi T (2014) Solitary intraosseous neurofibroma of the mandible. Zahedan J Res Med Sci 16:42–44 Saravani S, Kadeh H, Nosratzehi T (2014) Solitary intraosseous neurofibroma of the mandible. Zahedan J Res Med Sci 16:42–44
12.
go back to reference Jangam SS, Ingole SN, Deshpande MD, Ranadive PA (2014) Solitary intraosseous neurofibroma: report of a unique case. Contemp Clin Dent 5(4):561–563CrossRef Jangam SS, Ingole SN, Deshpande MD, Ranadive PA (2014) Solitary intraosseous neurofibroma: report of a unique case. Contemp Clin Dent 5(4):561–563CrossRef
13.
go back to reference Deichler J, Martínez R, Niklander S, Seguel H, Marshall M, Esguep A (2011) Solitary intraosseous neurofibroma of the mandible. Apropos of a case. Med Oral Patol Oral Cir Bucal 16(6):e704–e707CrossRef Deichler J, Martínez R, Niklander S, Seguel H, Marshall M, Esguep A (2011) Solitary intraosseous neurofibroma of the mandible. Apropos of a case. Med Oral Patol Oral Cir Bucal 16(6):e704–e707CrossRef
14.
go back to reference Tao Q, Wang Y, Zheng C (2010) Neurofibroma in the left mandible: a case report. Kaohsiung J Med Sci 26(4):217–221CrossRef Tao Q, Wang Y, Zheng C (2010) Neurofibroma in the left mandible: a case report. Kaohsiung J Med Sci 26(4):217–221CrossRef
15.
go back to reference Alatli C, Oner B, Unür M, Erseven G (1996) Solitary plexiform neurofibroma of the oral cavity a case report. Int J Oral Maxillofac Surg 25(5):379–380CrossRef Alatli C, Oner B, Unür M, Erseven G (1996) Solitary plexiform neurofibroma of the oral cavity a case report. Int J Oral Maxillofac Surg 25(5):379–380CrossRef
16.
go back to reference Ueda M, Suzuki H, Kaneda T (1993) Solitary intraosseous neurofibroma of the mandible: report of a case. Nagoya J Med Sci 55(1–4):97–101 Ueda M, Suzuki H, Kaneda T (1993) Solitary intraosseous neurofibroma of the mandible: report of a case. Nagoya J Med Sci 55(1–4):97–101
17.
go back to reference Papageorge MB, Doku HC, Lis R (1992) Solitary neurofibroma of the mandible and infratemporal fossa in a young child. Report of a case. Oral Surg Oral Med Oral Pathol 73(4):407–411CrossRef Papageorge MB, Doku HC, Lis R (1992) Solitary neurofibroma of the mandible and infratemporal fossa in a young child. Report of a case. Oral Surg Oral Med Oral Pathol 73(4):407–411CrossRef
18.
go back to reference Weaver BD, Graves RW, Keyes GG, Lattanzi DA (1991) Central neurofibroma of the mandible: report of a case. J Oral Maxillofac Surg 49(11):1243–1246CrossRef Weaver BD, Graves RW, Keyes GG, Lattanzi DA (1991) Central neurofibroma of the mandible: report of a case. J Oral Maxillofac Surg 49(11):1243–1246CrossRef
19.
go back to reference Polak M, Polak G, Brocheriou C, Vigneul J (1989) Solitary neurofibroma of the mandible: case report and review of the literature. J Oral Maxillofac Surg 47(1):65–68CrossRef Polak M, Polak G, Brocheriou C, Vigneul J (1989) Solitary neurofibroma of the mandible: case report and review of the literature. J Oral Maxillofac Surg 47(1):65–68CrossRef
20.
go back to reference Gnepp DR, Keyes GG (1981) Central neurofibroma of the mandible. J Oral Surg 39:125 Gnepp DR, Keyes GG (1981) Central neurofibroma of the mandible. J Oral Surg 39:125
21.
go back to reference Larsson A, Praetorius F, Hjörting-Hansen E (1978) Intraosseous neurofibroma of the jaws. Int J Oral Surg 7(5):494–499CrossRef Larsson A, Praetorius F, Hjörting-Hansen E (1978) Intraosseous neurofibroma of the jaws. Int J Oral Surg 7(5):494–499CrossRef
22.
go back to reference Ellis GL, Abrams AM, Melrose RJ (1977) Intraosseous benign neural sheath neoplasms of the jaws. Report of seven new cases and review of the literature. Oral Surg Oral Med Oral Pathol 44(5):731–743CrossRef Ellis GL, Abrams AM, Melrose RJ (1977) Intraosseous benign neural sheath neoplasms of the jaws. Report of seven new cases and review of the literature. Oral Surg Oral Med Oral Pathol 44(5):731–743CrossRef
23.
go back to reference Singer CF Jr, Gienger GL, Kullbom TL (1973) Solitary intraosseous neurofibroma involving the mandibular canal: report of case. J Oral Surg 31(2):127–129 Singer CF Jr, Gienger GL, Kullbom TL (1973) Solitary intraosseous neurofibroma involving the mandibular canal: report of case. J Oral Surg 31(2):127–129
24.
go back to reference Cundy RL, Matukas VJ (1972) Solitary intraosseous neurofibroma of the mandible. Arch Otolaryngol 96(1):81–83CrossRef Cundy RL, Matukas VJ (1972) Solitary intraosseous neurofibroma of the mandible. Arch Otolaryngol 96(1):81–83CrossRef
25.
go back to reference Prescott GH, White RE (1970) Solitary, central neurofibroma of the mandible: report of case and review of the literature. J Oral Surg 28(4):305–309 Prescott GH, White RE (1970) Solitary, central neurofibroma of the mandible: report of case and review of the literature. J Oral Surg 28(4):305–309
26.
go back to reference Cassalia PT, Miller AS (1971) Solitary central neurofibroma of the mandible. Br J Oral Surg 8(3):270–272CrossRef Cassalia PT, Miller AS (1971) Solitary central neurofibroma of the mandible. Br J Oral Surg 8(3):270–272CrossRef
27.
go back to reference Sharawy A, Springer J (1968) Central neurofibroma occurring in the mandible. Report of a case. Oral Surg Oral Med Oral Pathol 25(6):817–821CrossRef Sharawy A, Springer J (1968) Central neurofibroma occurring in the mandible. Report of a case. Oral Surg Oral Med Oral Pathol 25(6):817–821CrossRef
28.
go back to reference Gutman D, Griffel B, Munk J, Shohat S (1964) Solitary neurofibroma of the mandible. Oral Surg Oral Med Oral Pathol 17:1–9CrossRef Gutman D, Griffel B, Munk J, Shohat S (1964) Solitary neurofibroma of the mandible. Oral Surg Oral Med Oral Pathol 17:1–9CrossRef
29.
go back to reference Villa VG, Laico JE, Banez LO (1962) Central neurofibroma in the mandible associated with occasional spontaneous haemorrhage. Report of a case. Oral Surg Oral Med Oral Pathol 15:836–842CrossRef Villa VG, Laico JE, Banez LO (1962) Central neurofibroma in the mandible associated with occasional spontaneous haemorrhage. Report of a case. Oral Surg Oral Med Oral Pathol 15:836–842CrossRef
30.
go back to reference Caldwell JB, Hughes KW, Cox RS Jr (1961) Neurofibroma of the mandible: report of case. J Oral Surg Anesth Hosp Dent Serv 19:166–167 Caldwell JB, Hughes KW, Cox RS Jr (1961) Neurofibroma of the mandible: report of case. J Oral Surg Anesth Hosp Dent Serv 19:166–167
31.
go back to reference Johnson HS, Wannamaker GT, Humes JJ, Thompson CW (1959) Central neurofibroma; report of a case. Oral Surg Oral Med Oral Pathol 12(3):379–383CrossRef Johnson HS, Wannamaker GT, Humes JJ, Thompson CW (1959) Central neurofibroma; report of a case. Oral Surg Oral Med Oral Pathol 12(3):379–383CrossRef
32.
go back to reference Cornell CF, Vargas HA (1955) Intraosseous neurofibroma of the mandible. Oral Surg Oral Med Oral Pathol 8(1):34–39CrossRef Cornell CF, Vargas HA (1955) Intraosseous neurofibroma of the mandible. Oral Surg Oral Med Oral Pathol 8(1):34–39CrossRef
33.
go back to reference Bruce KW (1954) Solitary neurofibroma (neurilemmoma, schwannoma) of the oral cavity. Oral Surg Oral Med Oral Pathol 7(11):1150–1159CrossRef Bruce KW (1954) Solitary neurofibroma (neurilemmoma, schwannoma) of the oral cavity. Oral Surg Oral Med Oral Pathol 7(11):1150–1159CrossRef
34.
go back to reference Blackwood HJ, Lucas RB (1951) Neurofibroma of the mandible. Proc R Soc Med 44(10):864–865 Blackwood HJ, Lucas RB (1951) Neurofibroma of the mandible. Proc R Soc Med 44(10):864–865
35.
go back to reference Goldman HM (1944) Case reports from the army medical museum. Am J Orthod 30:265 Goldman HM (1944) Case reports from the army medical museum. Am J Orthod 30:265
Metadata
Title
Solitary Neurofibroma of Mandible in a 2-Year-Old Child: A Rare Case Report and Review of Literature
Authors
Dibya Falgoon Sarkar
Niranjan Mishra
Debashish Pati
Sandeep Kumar Samal
Publication date
16-11-2021
Publisher
Springer India
Published in
Journal of Maxillofacial and Oral Surgery / Issue 4/2022
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI
https://doi.org/10.1007/s12663-021-01670-6

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