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Acta Neurochirurgica

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01-02-2011 | Clinical Article

Solitary fibrous tumors of the central nervous system: report of five cases with unusual clinicopathological and outcome patterns

Authors: François Vassal, Romain Manet, Fabien Forest, Jean Phillipe Camdessanche, Michel Péoc’h, Christophe Nuti

Published in: Acta Neurochirurgica | Issue 2/2011

Abstract

Background

This is a retrospective study of 11 patients harboring a solitary fibrous tumor (SFT) of the central nervous system (CNS), with special emphasis on unusual clinicopathological and outcomes patterns.

Method

Between 2000 and 2008, 11 patients harboring CNS SFTs were treated at our institution. Patient charts were retrospectively reviewed and tumor location, clinical presentation, imaging characteristics, extent of resection, dural origin, pathological features, adjuvant treatment, and follow-up data were collected, focusing on five atypical cases (four intracranial and one within the spine).

Findings

One intracranial SFT arose from the sella turcica and relapsed threefold during the 6 years following partial removal. Disease progressed as successive isolated local recurrences treated by subsequent surgical interventions and gamma-knife radiosurgery. The MiB-1 labeling index analysis showed a steady increase in these sequential recurrences (ranging from less than 3% up to 6%) without obvious malignant transformation. The second SFT occurred in the cerebellopontine angle and exhibited a high MiB-1 index (10%) without noticeable features of malignancy. It relapsed twice during the 5 years following gross total resection without demonstrating a more aggressive histological pattern. The third SFT arose from the cerebellar tentorium, widely invaded the lateral sinus and adjacent bone, had a low MiB-1 index, and has not recurred within the 2 years after incomplete resection. The two remaining SFTs presented with unusual clinicoradiological features. We described a extremely rare case of intraventricular SFT, and a case of extradural SFT of the thoracic spine (T8–T9) radiologically consistent with a schwannoma. Immunohistochemistry confirmed that all tumors were SFTs.

Conclusions

These atypical presentations gave us the opportunity to provide further information about the variability of the clinicoradiological patterns and natural histological course of CNS SFTs.

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Title: Solitary fibrous tumors of the central nervous system: report of five cases with unusual clinicopathological and outcome patterns
Authors: François Vassal
Romain Manet
Fabien Forest
Jean Phillipe Camdessanche
Michel Péoc’h
Christophe Nuti
Publication date: 01-02-2011
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 2/2011
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-010-0866-4

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Springer Medicine

Solitary fibrous tumors of the central nervous system: report of five cases with unusual clinicopathological and outcome patterns

Abstract

Background

Method

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Findings

Conclusions

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