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01-07-2014 | Case Report

Soft tissue perineurioma of the foot with 10q24 rearrangements: unique MRI features with histopathologic correlation

Authors: Jun Nishio, Hiroshi Iwasaki, Hiroyuki Hayashi, Kazuki Nabeshima, Masatoshi Naito

Published in: Skeletal Radiology | Issue 7/2014

Abstract

Perineurioma is an uncommon benign peripheral nerve sheath tumor with advanced perineurial differentiation. Two distinct subtypes are recognized: intraneural and soft tissue. We herein present a unique case of soft tissue perineurioma in the right foot of a 43-year-old man. Radiographs showed a non-specific soft tissue mass. On computed tomography scan, the mass was iso- to slightly hypodense relative to muscle. On T1- and T2-weighted images, the mass exhibited iso- to slightly low signal intensity relative to muscle with foci of high signal intensity. Slight contrast enhancement was noted on enhanced T1-weighted images with fat suppression. A marginal excision of the tumor was performed and histopathologic examination confirmed the diagnosis of soft tissue perineurioma. The clinicopathologic, radiologic, and cytogenetic findings are described, and the relevant literature is reviewed.

Hornick JL, Fletcher CDM. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29:845–58.PubMedCrossRef

Miyake M, Tateishi U, Maeda T, et al. Sclerosing perineurioma: tumor of the hand with a short T2. Skeletal Radiol. 2006;35:543–6.PubMedCrossRef

Miyake M, Tateishi U, Maeda T, Arai Y, Seki K, Sugimura K. Computed tomography and magnetic resonance imaging findings of soft tissue perineurioma. Radiat Med. 2008;26:368–71.PubMedCrossRef

Yasumoto M, Katada Y, Matsumoto R, Adachi A, Kaneko K. Soft-tissue perineurioma of the retroperitoneum in a 63-year-old man, computed tomography and magnetic resonance imaging findings: a case report. J Med Case Rep. 2010;4:290.PubMedCentralPubMedCrossRef

Kim HJ, Yang I, Jung AY, et al. Ultrasound and MR findings in sclerosing perineurioma. Skeletal Radiol. 2011;40:353–5.PubMedCrossRef

Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB. Intraneural perineurioma: a clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol. 1995;103:696–704.PubMed

Giannini C, Scheithauer BW, Jenkins RB, et al. Soft-tissue perineurioma: evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol. 1997;21:164–73.PubMedCrossRef

Sciot R, Dal Cin P, Hagemeijer A, De Smet L, Van Damme B, Van den Berghe H. Cutaneous sclerosing perineurioma with cryptic NF2 gene deletion. Am J Surg Pathol. 1999;23:849–53.PubMedCrossRef

Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005;29:1164–9.PubMedCrossRef

10.

Lazarus SS, Trombetta LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer. 1978;41:1823–9.PubMedCrossRef

11.

Folpe AL, Billings SD, McKenney JK, Walsh SV, Nusrat A, Weiss SW. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol. 2002;26:1620–6.PubMedCrossRef

12.

Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol. 2003;16:293–8.PubMedCrossRef

13.

Zamecnik M. Perineurioma with adipocytes (lipomatous perineurioma). Am J Dermatopathol. 2003;25:171–3.PubMedCrossRef

14.

Macarenco AC, Macarenco RS. Cutaneous lipomatous sclerosing perineurioma. Am J Dermatopathol. 2008;30:291–4.PubMedCrossRef

15.

Simmons Z, Mahadeen ZI, Kothari MJ, Powers S, Wise S, Towfighi J. Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. Muscle Nerve. 1999;22:28–36.PubMedCrossRef

16.

Wadhwa V, Thakkar RS, Maragakis N, et al. Sciatic nerve tumor and tumor-like lesions: uncommon pathologies. Skeletal Radiol. 2012;41:763–74.PubMedCrossRef

17.

Nacey NC, Almira Suarez MI, Mandell JW, Anderson MW, Gaskin CM. Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings. Skeletal Radiol. 2014;43:375–9.

18.

Nishio J. Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors. Oncol Lett. 2013;5:12–8.PubMedCentralPubMed

19.

Macchia G, Trombetta D, Möller E, et al. FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma. Lab Invest. 2012;92:735–43.PubMedCrossRef

20.

Yamamoto A, Abe S, Imamura T, et al. Three cases of collagenous fibroma with rim enhancement on postcontrast T1-weighted images with fat suppression. Skeletal Radiol. 2013;42:141–6.PubMedCrossRef

21.

Nishio J, Iwasaki H, Yano S, Naito M. Collagenous fibroma (desmoplastic fibroblastoma) with trisomy 8 as the sole cytogenetic abnormality. Anticancer Res. 2013;33:3259–62.PubMed

22.

Möller E, Mandahl N, Mertens F, Panagopoulos I. Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. Genes Chromosomes Cancer. 2008;47:21–5.PubMedCrossRef

23.

Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics. 2008;28:1493–518.PubMedCrossRef

24.

Mott RT, Goodman BK, Burchette JL, Cummings TJ. Loss of chromosome 13 in a case of soft tissue perineurioma. Clin Neuropathol. 2005;24:69–76.PubMed

Title: Soft tissue perineurioma of the foot with 10q24 rearrangements: unique MRI features with histopathologic correlation
Authors: Jun Nishio
Hiroshi Iwasaki
Hiroyuki Hayashi
Kazuki Nabeshima
Masatoshi Naito
Publication date: 01-07-2014
Publisher: Springer Berlin Heidelberg
Published in: Skeletal Radiology / Issue 7/2014
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-014-1839-0

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Soft tissue perineurioma of the foot with 10q24 rearrangements: unique MRI features with histopathologic correlation

Abstract

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Abstract

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